The use of olanzapine as an antiemetic in ...
Document type :
Article dans une revue scientifique: Article original
PMID :
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Title :
The use of olanzapine as an antiemetic in palliative medicine: a systematic review of the literature.
Author(s) :
Saudemont, Gaëtan [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
PROD'HOMME, CHLOE [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Da Silva, A. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Villet, Stéphanie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Reich, Georges Michel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Reich, Georges Michel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
PROD'HOMME, CHLOE [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Da Silva, A. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Villet, Stéphanie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Reich, Georges Michel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Penel, Nicolas [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Reich, Georges Michel [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Journal title :
BMC Palliative Care
Abbreviated title :
BMC Palliat Care
Volume number :
19
Pages :
56
Publication date :
2020-04-25
ISSN :
1472-684X
English keyword(s) :
Palliative medicine
Antiemetic treatment
Atypical antipsychotic
Olanzapine
Antiemetic treatment
Atypical antipsychotic
Olanzapine
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background
Olanzapine is an atypical antipsychotic that has affinity for many central nervous system receptors. Its efficacy is supported by several studies in the prevention and treatment of chemotherapy-induced nausea ...
Show more >Background Olanzapine is an atypical antipsychotic that has affinity for many central nervous system receptors. Its efficacy is supported by several studies in the prevention and treatment of chemotherapy-induced nausea and vomiting. No recommendations exist on the antiemetic use of olanzapine in the palliative care setting. The aim of this work is to complete the initial work of Fonte et al. published in 2015, to determine whether the literature supports the use of olanzapine as an antiemetic in palliative situations and, in practice, to propose a therapeutic schema adapted to the palliative setting. Methods Systematic review of the literature according to the PRISMA criteria. We searched the PubMed, Cochrane, RefDoc, EMBase databases and the gray literature databases. The bibliographic search was conducted between November 2016 and August 2017. Results Thirteen articles were included: 2 case studies, 3 case series, 3 retrospective studies, 2 prospective studies, 2 literature reviews. All studies concluded on the efficacy of olanzapine as an antiemetic in the palliative care setting. No serious adverse effects were reported. Based on the data from the literature review, we propose a therapeutic scheme adapted to the palliative care context. Conclusion Action of olanzapine on many receptors and its tolerance profile make it an interesting antiemetic treatment in palliative medicine. But to date, studies are scarce and have a low statistical power. Further investigation is therefore needed to determine the benefit of this treatment in palliative care patients, compared to usual treatments.Show less >
Show more >Background Olanzapine is an atypical antipsychotic that has affinity for many central nervous system receptors. Its efficacy is supported by several studies in the prevention and treatment of chemotherapy-induced nausea and vomiting. No recommendations exist on the antiemetic use of olanzapine in the palliative care setting. The aim of this work is to complete the initial work of Fonte et al. published in 2015, to determine whether the literature supports the use of olanzapine as an antiemetic in palliative situations and, in practice, to propose a therapeutic schema adapted to the palliative setting. Methods Systematic review of the literature according to the PRISMA criteria. We searched the PubMed, Cochrane, RefDoc, EMBase databases and the gray literature databases. The bibliographic search was conducted between November 2016 and August 2017. Results Thirteen articles were included: 2 case studies, 3 case series, 3 retrospective studies, 2 prospective studies, 2 literature reviews. All studies concluded on the efficacy of olanzapine as an antiemetic in the palliative care setting. No serious adverse effects were reported. Based on the data from the literature review, we propose a therapeutic scheme adapted to the palliative care context. Conclusion Action of olanzapine on many receptors and its tolerance profile make it an interesting antiemetic treatment in palliative medicine. But to date, studies are scarce and have a low statistical power. Further investigation is therefore needed to determine the benefit of this treatment in palliative care patients, compared to usual treatments.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Submission date :
2023-11-15T08:57:43Z
2024-01-08T13:16:56Z
2024-01-08T13:16:56Z
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