Epidemiology of Community-Onset Severe ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Epidemiology of Community-Onset Severe Bacterial Infections in Children and Its Evolution: A Population-Based Study in France.
Author(s) :
Lorton, Fleur [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Chalumeau, Martin [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Martinot, Alain [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Assathiany, Rémy [Auteur]
Association Française de Pédiatrie Ambulatoire [AFPA]
Roué, Jean-Michel [Auteur]
CHRU de Brest - Département de Pédiatrie [CHU BREST Pédiatrie]
Bourgoin, Pierre [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Chantreuil, Julie [Auteur]
CHU Trousseau [Tours]
Boussicault, Gérald [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Gaillot, Théophile [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Saulnier, Jean-Pascal [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Caillon, Jocelyne [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Levy, Corinne [Auteur]
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Cohen, Robert [Auteur]
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Gras-Le Guen, Christèle [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Launay, Elise [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Chalumeau, Martin [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Martinot, Alain [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Assathiany, Rémy [Auteur]
Association Française de Pédiatrie Ambulatoire [AFPA]
Roué, Jean-Michel [Auteur]
CHRU de Brest - Département de Pédiatrie [CHU BREST Pédiatrie]
Bourgoin, Pierre [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Chantreuil, Julie [Auteur]
CHU Trousseau [Tours]
Boussicault, Gérald [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Gaillot, Théophile [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Saulnier, Jean-Pascal [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Caillon, Jocelyne [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Levy, Corinne [Auteur]
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Cohen, Robert [Auteur]
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Gras-Le Guen, Christèle [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Launay, Elise [Auteur]
Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique [EPOPé [CRESS - U1153 / UMR_A 1125]]
Journal title :
Pediatric Critical Care Medicine
Abbreviated title :
Pediatr Crit Care Med
Volume number :
21
Pages :
e325-e332
Publication date :
2020-04-04
ISSN :
1529-7535
English keyword(s) :
incidence
morbidity
mortality
sepsis
severe bacterial infection
vaccination
morbidity
mortality
sepsis
severe bacterial infection
vaccination
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Objectives:
To describe the epidemiology of community-onset severe bacterial infections in children and its recent evolution.
Design:
Prospective, observational, population-based study from 2009 to 2014.
Setting: ...
Show more >Objectives: To describe the epidemiology of community-onset severe bacterial infections in children and its recent evolution. Design: Prospective, observational, population-based study from 2009 to 2014. Setting: An administrative area accounting for 13% of the French pediatric population. Patients: All children 1 month to 16 years old who died before admission or were admitted to a PICU for a community-onset severe bacterial infection. Interventions: None. Measurements and Main Results: The incidence and mortality rate of community-onset severe bacterial infections were compared with data from a reference population-based study conducted between 2000 and 2006, that is, before national recommendations for antimeningococcal C and antipneumococcal generalized vaccinations. Among the 261 children included (median age 25 mo), 28 (10.7%) died. The main diagnoses were meningitis (n = 85; 32%) and purpura fulminans (n = 59; 22%). The most common isolated bacteria were Neisseria meningitidis (n = 75; 29%), including 47 (63%) cases of serogroup B and 15 (20%) serogroup C, Streptococcus pneumoniae (n = 49, 19%), and Staphylococcus aureus (n = 15; 6%). The incidence of community-onset severe bacterial infections was three per 100,000 person-years (95% CI, 2.6–3.3) and had decreased by 53% from the reference period. Mortality rate was 0.3 per 100,000 person-years (95% CI, 0.2–0.4) and had decreased by 73% from the reference period. The incidence of community-onset severe bacterial infections caused by N. meningitidis and S. pneumoniae was 0.8 and 0.5 per 100,000 person-years and had decreased by 70% and 67% from the reference period. The incidence of community-onset severe bacterial infections–related to Staphylococcus aureus was 0.16 per 100,000 person-years and had increased by 220% from the reference period. Conclusions: The incidence and mortality rate of community-onset severe bacterial infections, except for S. aureus infection, have decreased in France. N. meningitidis and S. pneumoniae continue to account for many infections, which indicates the need for better vaccination coverage and spectrum.Show less >
Show more >Objectives: To describe the epidemiology of community-onset severe bacterial infections in children and its recent evolution. Design: Prospective, observational, population-based study from 2009 to 2014. Setting: An administrative area accounting for 13% of the French pediatric population. Patients: All children 1 month to 16 years old who died before admission or were admitted to a PICU for a community-onset severe bacterial infection. Interventions: None. Measurements and Main Results: The incidence and mortality rate of community-onset severe bacterial infections were compared with data from a reference population-based study conducted between 2000 and 2006, that is, before national recommendations for antimeningococcal C and antipneumococcal generalized vaccinations. Among the 261 children included (median age 25 mo), 28 (10.7%) died. The main diagnoses were meningitis (n = 85; 32%) and purpura fulminans (n = 59; 22%). The most common isolated bacteria were Neisseria meningitidis (n = 75; 29%), including 47 (63%) cases of serogroup B and 15 (20%) serogroup C, Streptococcus pneumoniae (n = 49, 19%), and Staphylococcus aureus (n = 15; 6%). The incidence of community-onset severe bacterial infections was three per 100,000 person-years (95% CI, 2.6–3.3) and had decreased by 53% from the reference period. Mortality rate was 0.3 per 100,000 person-years (95% CI, 0.2–0.4) and had decreased by 73% from the reference period. The incidence of community-onset severe bacterial infections caused by N. meningitidis and S. pneumoniae was 0.8 and 0.5 per 100,000 person-years and had decreased by 70% and 67% from the reference period. The incidence of community-onset severe bacterial infections–related to Staphylococcus aureus was 0.16 per 100,000 person-years and had increased by 220% from the reference period. Conclusions: The incidence and mortality rate of community-onset severe bacterial infections, except for S. aureus infection, have decreased in France. N. meningitidis and S. pneumoniae continue to account for many infections, which indicates the need for better vaccination coverage and spectrum.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Submission date :
2023-11-15T09:06:25Z
2023-12-19T09:40:50Z
2023-12-19T09:40:50Z