Title :

The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study.

Author(s) :

Tosello, Barthélémy [Auteur]
Aix Marseille Université [AMU]
Garbi, Aurélie [Auteur]
Hôpital Nord [CHU - APHM]
Blanc, Julie [Auteur]
Centre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
Lorthe, Elsa [Auteur]
Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique [CRESS - U1153]
Foix-L'Hélias, Laurence [Auteur]
Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique [CRESS - U1153]
d'Ercole, Claude [Auteur]
Hôpital Nord [CHU - APHM]
Winer, Norbert [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Subtil, Damien [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Goffinet, François [Auteur]
CHU Trousseau [APHP]
Kayem, Gilles [Auteur]
Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique [CRESS - U1153]
Resseguier, Noémie [Auteur]
Centre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
Gire, Catherine [Auteur]
Hôpital Nord [CHU - APHM]

Journal title :

BJOG: An International Journal of Obstetrics and Gynaecology

Abbreviated title :

BJOG

Volume number :

128

Pages :

281-291

Publication date :

2020-02-15

ISSN :

1471-0528

English keyword(s) :

Chorionicity
EPIPAGE-2
monochorionic pregnancies
neonatal outcomes
prematurity
preterm birth
twins
2-year outcome

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective To compare the short- and mid-term outcomes of preterm twins by chorionicity of pregnancy. Design Prospective nationwide population-based EPIPAGE-2 cohort study. Setting 546 maternity units in ...
Show more >Objective To compare the short- and mid-term outcomes of preterm twins by chorionicity of pregnancy. Design Prospective nationwide population-based EPIPAGE-2 cohort study. Setting 546 maternity units in France, between March and December 2011. Population A total of 1700 twin neonates born between 24 and 34 weeks of gestation. Methods The association of chorionicity with outcomes was analysed using multivariate regression models. Main outcome measures First, survival at 2-year corrected age with or without neurosensory impairment, and second, perinatal, short-, and mid-term outcomes (survival at discharge, survival at discharge without severe morbidity) were described and compared by chorionicity. Results In the EPIPAGE 2 cohort, 1700 preterm births were included (850 twin pregnancies). In all, 1220 (71.8%) were from dichorionic (DC) pregnancies and 480 from monochorionic (MC) pregnancies. MC pregnancies had three times more medical terminations than DC pregnancies (1.67 versus 0.51%, P < 0.001), whereas there were three times more stillbirths in MC than in DC pregnancies (10.09 versus 3.78%, P < 0.001). Both twins were alive at birth in 86.6% of DC pregnancies compared with 80.0% among MC pregnancies (P = 0.008). No significant difference according to chorionicity was found regarding neonatal deaths and morbidities. Likewise, for children born earlier than 32 weeks, the 2-year follow-up neurodevelopmental results were not significantly different between DC and MC twins. Conclusions This study confirms that MC pregnancies have a higher risk of adverse outcomes. However, the outcomes among preterm twins admitted to neonatal intensive care units are similar irrespective of chorionicity.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T09:24:26Z
2024-01-08T08:55:43Z