Exposure to multiple air pollutants and ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Exposure to multiple air pollutants and the incidence of coronary heart disease: A fine-scale geographic analysis.
Auteur(s) :
Occelli, Florent [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Lanier, Caroline [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Cuny, Damien [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Deram, Annabelle [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Dumont, Julie [Auteur]
Médicaments et Molécules pour agir sur les Systèmes Vivants (M2SV) - U1177
Amouyel, Philippe [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Montaye, Michele [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Dauchet, Luc [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Dallongeville, Jean [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Genin, Michaël [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
![refId](/themes/Mirage2//images/idref.png)
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Lanier, Caroline [Auteur]
![refId](/themes/Mirage2//images/idref.png)
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Cuny, Damien [Auteur]
![refId](/themes/Mirage2//images/idref.png)
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Deram, Annabelle [Auteur]
![refId](/themes/Mirage2//images/idref.png)
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Dumont, Julie [Auteur]
Médicaments et Molécules pour agir sur les Systèmes Vivants (M2SV) - U1177
Amouyel, Philippe [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Montaye, Michele [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Dauchet, Luc [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Dallongeville, Jean [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Genin, Michaël [Auteur]
![refId](/themes/Mirage2//images/idref.png)
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Titre de la revue :
Science of the Total Environment
Nom court de la revue :
Sci. Total Environ.
Numéro :
714
Pagination :
136608
Date de publication :
2020-02-07
ISSN :
1879-1026
Mot(s)-clé(s) en anglais :
Cardiovascular disease
Heavy metal
Traffic pollution
Composite index
Multiple exposure
Heavy metal
Traffic pollution
Composite index
Multiple exposure
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Geographical variations in cardiovascular disease rates have been linked to individual air pollutants. Investigating the relation between cardiovascular disease and exposure to a complex mixture of air pollutants requires ...
Lire la suite >Geographical variations in cardiovascular disease rates have been linked to individual air pollutants. Investigating the relation between cardiovascular disease and exposure to a complex mixture of air pollutants requires holistic approaches. We assessed the relationship between exposure to multiple air pollutants and the incidence of coronary heart disease (CHD) in a general population sample. We collected data in the Lille MONICA registry (2008–2011) on 3268 incident cases (age range: 35–74). Based on 20 indicators, we derived a composite environmental score (SEnv) for cumulative exposure to air pollution. Poisson regression models were used to analyse associations between CHD rates on one hand and SEnv and each single indicator on the other (considered in tertiles, where T3 is the most contaminated). We adjusted models for age, sex, area-level social deprivation, and neighbourhood spatial structure. The incidence of CHD was a spatially heterogeneous (p=0.006). There was a significant positive association between SEnv and CHD incidence (trend p=0.0151). The relative risks [95%CI] of CHD were 1.08 [0.98–1.18] and 1.16 [1.04–1.29] for the 2nd and 3rd tertile of SEnv exposure. In the single pollutant analysis, PM10, NO2, cadmium, copper, nickel, and palladium were significantly associated with CHD rates. Multiple air pollution was associated with an increased risk of CHD. Single pollutants reflecting road traffic pollution were the most strongly associated with CHD. Our present results are consistent with the literature data on the impact of road traffic on the CHD risk in urban areas.Lire moins >
Lire la suite >Geographical variations in cardiovascular disease rates have been linked to individual air pollutants. Investigating the relation between cardiovascular disease and exposure to a complex mixture of air pollutants requires holistic approaches. We assessed the relationship between exposure to multiple air pollutants and the incidence of coronary heart disease (CHD) in a general population sample. We collected data in the Lille MONICA registry (2008–2011) on 3268 incident cases (age range: 35–74). Based on 20 indicators, we derived a composite environmental score (SEnv) for cumulative exposure to air pollution. Poisson regression models were used to analyse associations between CHD rates on one hand and SEnv and each single indicator on the other (considered in tertiles, where T3 is the most contaminated). We adjusted models for age, sex, area-level social deprivation, and neighbourhood spatial structure. The incidence of CHD was a spatially heterogeneous (p=0.006). There was a significant positive association between SEnv and CHD incidence (trend p=0.0151). The relative risks [95%CI] of CHD were 1.08 [0.98–1.18] and 1.16 [1.04–1.29] for the 2nd and 3rd tertile of SEnv exposure. In the single pollutant analysis, PM10, NO2, cadmium, copper, nickel, and palladium were significantly associated with CHD rates. Multiple air pollution was associated with an increased risk of CHD. Single pollutants reflecting road traffic pollution were the most strongly associated with CHD. Our present results are consistent with the literature data on the impact of road traffic on the CHD risk in urban areas.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Date de dépôt :
2023-11-15T09:27:44Z
2023-12-15T12:08:00Z
2023-12-15T12:08:00Z
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