Treatment of Head Louse Infestation with ...
Document type :
Article dans une revue scientifique: Article original
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Title :
Treatment of Head Louse Infestation with a Novel Mixture Made of Semi-Crystalline Polymers and Plant Extracts: Blind, Randomized, Controlled, Superiority Trial
Author(s) :
Cardoso, J. H. L. [Auteur]
De Souza, A. N. C. [Auteur]
De Souza, F. M. [Auteur]
Preire, S. S. [Auteur]
Pinçon, Claire [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
De Souza, A. N. C. [Auteur]
De Souza, F. M. [Auteur]
Preire, S. S. [Auteur]
Pinçon, Claire [Auteur]

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Journal title :
Cosmetics
Abbreviated title :
Cosmetics
Volume number :
7
Pages :
p. 1-18
Publication date :
2020
ISSN :
2079-9284
English keyword(s) :
head lice
treatment
shampoo
Pediculus humanus capitis
clinical trial
clinical study
randomized
blinded
controlled
treatment
shampoo
Pediculus humanus capitis
clinical trial
clinical study
randomized
blinded
controlled
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The rate of head louse infestations is increasing. Most of the neurotoxic treatments are not reliably ovicidal and are faced with genetic resistance. The treatments based on a mechanical mode of action show no sufficient ...
Show more >The rate of head louse infestations is increasing. Most of the neurotoxic treatments are not reliably ovicidal and are faced with genetic resistance. The treatments based on a mechanical mode of action show no sufficient efficacy, transferring the chances of a cure on a tedious combing or leaving the hair fatty. This double-blinded, randomized, controlled, superiority trial evaluates the efficacy and safety of a novel mixture made of semi-crystalline polymers and plant extracts. Forty-five participants received a single application of either 1% Permethrin lotion or the novel lotion, applied for 15 minutes. Untreated and treated nits were collected and placed in an incubator during 10 days. The worst case intent-to-treat analysis found the novel lotion significantly more effective than 1% Permethrin, with 21/22 (95.5%) participants cured and 9/23 (39.1%), respectively (p < 0.0001). Rate of viable nymphs was 0.5 (2.1) for the new lotion and 40.8 (20.4) for the 1% Permethrin. The new lotion cures head louse infestations, offering an effective alternative treatment, with a high efficacy for inhibiting the hatching of eggs. Its physical actions on lice and their eggs should not be affected by resistance to neurotoxic insecticidesShow less >
Show more >The rate of head louse infestations is increasing. Most of the neurotoxic treatments are not reliably ovicidal and are faced with genetic resistance. The treatments based on a mechanical mode of action show no sufficient efficacy, transferring the chances of a cure on a tedious combing or leaving the hair fatty. This double-blinded, randomized, controlled, superiority trial evaluates the efficacy and safety of a novel mixture made of semi-crystalline polymers and plant extracts. Forty-five participants received a single application of either 1% Permethrin lotion or the novel lotion, applied for 15 minutes. Untreated and treated nits were collected and placed in an incubator during 10 days. The worst case intent-to-treat analysis found the novel lotion significantly more effective than 1% Permethrin, with 21/22 (95.5%) participants cured and 9/23 (39.1%), respectively (p < 0.0001). Rate of viable nymphs was 0.5 (2.1) for the new lotion and 40.8 (20.4) for the 1% Permethrin. The new lotion cures head louse infestations, offering an effective alternative treatment, with a high efficacy for inhibiting the hatching of eggs. Its physical actions on lice and their eggs should not be affected by resistance to neurotoxic insecticidesShow less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Submission date :
2023-11-15T09:54:03Z
2024-04-08T14:06:04Z
2024-04-08T14:06:04Z
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