Self-Immolative Polymers for Nanoparticles with Unique Degradation Profiles in Biomedical Applications

Belkhir, Kedafi; Potier, Jonathan; Le Fer, Gaëlle; Woisel, Patrice

Document type :

Autre communication scientifique (congrès sans actes - poster - séminaire...): Communication dans un congrès sans actes

Permalink :

http://hdl.handle.net/20.500.12210/91734

Title :

Self-Immolative Polymers for Nanoparticles with Unique Degradation Profiles in Biomedical Applications

Author(s) :

Belkhir, Kedafi [Orateur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Potier, Jonathan [Collaborateur]

Unité Matériaux et Transformations (UMET) - UMR 8207
Le Fer, Gaëlle [Collaborateur]

Unité Matériaux et Transformations (UMET) - UMR 8207
Woisel, Patrice [Collaborateur]

Unité Matériaux et Transformations (UMET) - UMR 8207

Conference title :

51ème Edition du Colloque National du Groupe Français des Polymères (GFP)

City :

Talence (Bordeaux)

Country :

France

Start date of the conference :

2023-11-20

HAL domain(s) :

Chimie/Polymères
Chimie/Matériaux

English abstract : [en]

Self-Immolative polymers (SIPs) are new class of polymers able to translate an external stimulus into a depolymerization reaction [1], this unique feature makes them suitable for applications in which temporary structures ...
Show more >Self-Immolative polymers (SIPs) are new class of polymers able to translate an external stimulus into a depolymerization reaction [1], this unique feature makes them suitable for applications in which temporary structures are needed, such as nanoparticles for drug delivery.[2] The incorporation of SIPs in such systems can lead to overcome important barriers in the field of drug delivery, such as passive release, inertia, interferences between the stimulus and the physiological parameters (T°, pH) etc. This work aims to extend SIPs domain from chemistry to macromolecular engineering, in order to design SIP-based amphiphilic bloc copolymers, and then stimuli-responsive nanoparticles for controlled and on-demand drug release. UV- and NIR-sensitive groups were combined with caprolactone rings in order to make ROP polymerizable monomers. Then the polymerization of these monomers was initiated by polyethylene glycol to make diblock and triblock amphiphilic copolymers. Thanks to their amphiphilic character, the copolymers make self-assemblies in solvents and encapsulate drug models. Since the copolymers contain SIP segments, the obtained self-assemblies can be dissociated by irradiation. Copolymers with different chain lengths and different PEG/SIP ratios were synthesized in this work. The self-assembling behavior of the copolymers was demonstrated. The depolymerization of the copolymers as well as the dissociation of the self-assemblies were monitored by different techniques. The on-demand and controlled release of Nile Red from these self-assemblies was demonstrated. By using SIP segments to make self-assemblies, it was possible to control quantitatively the kinetics of the degradation of the copolymers. As consequence, the dissociation of the nanoparticles could be triggered, and the dissociation kinetics could be controlled. The Nile Red was successfully used as model to demonstrate the possibility to trigger and control the drug-release from the self-assembliesShow less >

Language :

Anglais

Peer reviewed article :

Non

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2023-11-29T10:38:03Z
2023-11-29T13:08:52Z
2024-02-07T10:05:11Z

Version	Link	Modification date
3	20.500.12210/91734*	2024-02-07T10:04:27Z
2	20.500.12210/91734.2	2023-11-29T13:06:58Z
1	20.500.12210/91734.1	2023-11-29T10:38:03Z

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Self-Immolative Polymers for Nanoparticles ... BibTeX CSV Excel RIS

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Self-Immolative Polymers for Nanoparticles ...

BibTeX

CSV

Excel

RIS