Human papillomavirus 42 drives digital ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Human papillomavirus 42 drives digital papillary adenocarcinoma and elicits a germ-cell like program conserved in HPV-positive cancers.
Author(s) :
Leiendecker, L. [Auteur]
Neumann, T. [Auteur]
Jung, P. S. [Auteur]
Cronin, S. M. [Auteur]
Steinacker, T. L. [Auteur]
Schleiffer, A. [Auteur]
Schutzbier, M. [Auteur]
Mechtler, K. [Auteur]
Kervarrec, T. [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Laurent, Estelle [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Bachiri, Kamel [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Coyaud, Etienne [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Murali, R. [Auteur]
Busam, K. J. [Auteur]
Itzinger-Monshi, B. [Auteur]
Kirnbauer, R. [Auteur]
Cerroni, L. [Auteur]
Calonje, E. [Auteur]
Rutten, A. [Auteur]
Stubenrauch, F. [Auteur]
Griewank, K. G. [Auteur]
Wiesner, T. [Auteur]
Obenauf, A. C. [Auteur]
Neumann, T. [Auteur]
Jung, P. S. [Auteur]
Cronin, S. M. [Auteur]
Steinacker, T. L. [Auteur]
Schleiffer, A. [Auteur]
Schutzbier, M. [Auteur]
Mechtler, K. [Auteur]
Kervarrec, T. [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Laurent, Estelle [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Bachiri, Kamel [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Coyaud, Etienne [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Murali, R. [Auteur]
Busam, K. J. [Auteur]
Itzinger-Monshi, B. [Auteur]
Kirnbauer, R. [Auteur]
Cerroni, L. [Auteur]
Calonje, E. [Auteur]
Rutten, A. [Auteur]
Stubenrauch, F. [Auteur]
Griewank, K. G. [Auteur]
Wiesner, T. [Auteur]
Obenauf, A. C. [Auteur]
Journal title :
Cancer discovery
Abbreviated title :
Cancer Discov
Publication date :
2022-10-17
ISSN :
2159-8290
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The skin is exposed to viral pathogens, but whether they contribute to the oncogenesis of skin cancers has not been systematically explored. Here we investigated 19 skin tumor types by analyzing off-target reads from ...
Show more >The skin is exposed to viral pathogens, but whether they contribute to the oncogenesis of skin cancers has not been systematically explored. Here we investigated 19 skin tumor types by analyzing off-target reads from commonly available next-generation sequencing data for viral pathogens. We identified human papillomavirus 42 (HPV42) in 96% (n = 45/47) of digital papillary adenocarcinoma (DPA), an aggressive cancer occurring on the fingers and toes. We show that HPV42, so far considered a nononcogenic, “low-risk” HPV, recapitulates the molecular hallmarks of oncogenic, “high-risk” HPVs. Using machine learning, we find that HPV-driven transformation elicits a germ cell–like transcriptional program conserved throughout all HPV-driven cancers (DPA, cervical carcinoma, and head and neck cancer). We further show that this germ cell–like transcriptional program, even when reduced to the top two genes (CDKN2A and SYCP2), serves as a fingerprint of oncogenic HPVs with implications for early detection, diagnosis, and therapy of all HPV-driven cancers.Show less >
Show more >The skin is exposed to viral pathogens, but whether they contribute to the oncogenesis of skin cancers has not been systematically explored. Here we investigated 19 skin tumor types by analyzing off-target reads from commonly available next-generation sequencing data for viral pathogens. We identified human papillomavirus 42 (HPV42) in 96% (n = 45/47) of digital papillary adenocarcinoma (DPA), an aggressive cancer occurring on the fingers and toes. We show that HPV42, so far considered a nononcogenic, “low-risk” HPV, recapitulates the molecular hallmarks of oncogenic, “high-risk” HPVs. Using machine learning, we find that HPV-driven transformation elicits a germ cell–like transcriptional program conserved throughout all HPV-driven cancers (DPA, cervical carcinoma, and head and neck cancer). We further show that this germ cell–like transcriptional program, even when reduced to the top two genes (CDKN2A and SYCP2), serves as a fingerprint of oncogenic HPVs with implications for early detection, diagnosis, and therapy of all HPV-driven cancers.Show less >
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Submission date :
2023-12-13T04:04:35Z
2024-01-29T14:56:08Z
2024-01-29T14:56:08Z
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