Title :

Impact of mesenchymal stem cells derived conditioned media on neural progenitor cells.

Author(s) :

Humenik, F. [Auteur]
Jego, S. [Auteur]
Hornakova, L. [Auteur]
Maloveska, M. [Auteur]
Valencakova-Agyagosova, A. [Auteur]
Vikartovska, Z. [Auteur]
Mudronova, D. [Auteur]
Hudakova, N. [Auteur]
Zilkova, M. [Auteur]
Cizek, M. [Auteur]
Cizkova, Dasa [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Journal title :

General Physiology and Biophysics

Abbreviated title :

Gen Physiol Biophys

Volume number :

40

Pages :

551-559

Publication date :

2021-12-21

ISSN :

0231-5882

English keyword(s) :

Neural progenitor cells
Mesenchymal stem cells
Umbilical cord
Adipose tissue neurite growth

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Neurodegenerative diseases are common problem for companion animals. Due to the limited ability of injured axons to regenerate, innovative therapies combined with rehabilitation have been applied and evaluated. Among ...
Show more >Neurodegenerative diseases are common problem for companion animals. Due to the limited ability of injured axons to regenerate, innovative therapies combined with rehabilitation have been applied and evaluated. Among them, stem cells and their conditioned media implantation, which can ameliorate damaged tissue has been suggested as a promising treatment strategy. The main goal of our study was to characterize mesenchymal stem cells (MSC) derived from canine adipose tissue (AT-MSC) and umbilical cord (UC-MSC) and analyse effect of their conditioned media (CM) on neurite outgrowth of neural progenitor cells isolated from the brain cortex of neonatal rats. MSC from both sources showed high osteogenic and chondrogenic potential and expression of CD90 and CD29. Furthermore, both UC-MSCCM and AT-MSCCM stimulated neurite growth. Interestingly, this effect was more pronounced with UC-MSCCM when compared to AT-MSCCM in vitro, which may be related to the different content of neurotrophic factors included in the CM.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2023-12-13T04:30:54Z
2024-01-30T16:17:05Z