Titre :

Impact of Functional Groups on the Copper-Initiated N-Arylation of 5-Functionalized Pyrrolidin-2-ones and Their Vinylogues

Auteur(s) :

Baudelet, Davy [Auteur]
Daich, Adam [Auteur]
Rigo, Benoit [Auteur]
Lipka, Emmanuelle [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Gautret, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Homerin, Germain [Auteur]
Claverie, Christelle [Auteur]
Rousseau, Jolanta [Auteur]
Abuhaie, Cristina-Maria [Auteur]
Ghinet, Alina [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995

Titre de la revue :

Synthesis

Nom court de la revue :

Synthesis

Numéro :

48

Pagination :

2226-2244

Date de publication :

2016-07-01

ISSN :

0039-7881

Mot(s)-clé(s) en anglais :

copper
arylation
heterogeneous catalysis
heterocycles
lactams
cross-coupling

Discipline(s) HAL :

Chimie/Catalyse
Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The electronic effects governing the N-arylation of pyrrolidone were investigated. The generalization of our preliminary findings on a copper(I)-catalyzed Csp2-N coupling process was first improved with a wide variety of ...
Lire la suite >The electronic effects governing the N-arylation of pyrrolidone were investigated. The generalization of our preliminary findings on a copper(I)-catalyzed Csp2-N coupling process was first improved with a wide variety of aryl and heteroaryl halides and methyl pyroglutamate. The optimized protocol was further extended to pyrrolidin-2-ones substituted at the C5-position with an aryl group bearing an electron-donating or electron-withdrawing group as well as to some of their substituted enaminoester vinylogues. The impact of substituents at the N- and C5-position on these coupling processes seemed to be pivotal for determining both the reaction profiles and yields.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
ENSCL
CNRS
Inserm
Centrale Lille
Univ. Artois
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Équipe(s) de recherche :

Catalyse et chimie supramoléculaire (CASU)
Therapeutic innovation targetting inflammation

Date de dépôt :

2019-05-17T13:14:40Z
2021-06-23T06:57:53Z