Impact of Functional Groups on the ...
Type de document :
Article dans une revue scientifique
DOI :
URL permanente :
Titre :
Impact of Functional Groups on the Copper-Initiated N-Arylation of 5-Functionalized Pyrrolidin-2-ones and Their Vinylogues
Auteur(s) :
Baudelet, Davy [Auteur]
Daich, Adam [Auteur]
Rigo, Benoit [Auteur]
Lipka, Emmanuelle [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Gautret, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Homerin, Germain [Auteur]
Claverie, Christelle [Auteur]
Rousseau, Jolanta [Auteur]
Abuhaie, Cristina-Maria [Auteur]
Ghinet, Alina [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Daich, Adam [Auteur]
Rigo, Benoit [Auteur]
Lipka, Emmanuelle [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Gautret, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Homerin, Germain [Auteur]
Claverie, Christelle [Auteur]
Rousseau, Jolanta [Auteur]
Abuhaie, Cristina-Maria [Auteur]
Ghinet, Alina [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Titre de la revue :
Synthesis
Nom court de la revue :
Synthesis
Numéro :
48
Pagination :
2226-2244
Date de publication :
2016-07-01
ISSN :
0039-7881
Mot(s)-clé(s) en anglais :
copper
arylation
heterogeneous catalysis
heterocycles
lactams
cross-coupling
arylation
heterogeneous catalysis
heterocycles
lactams
cross-coupling
Discipline(s) HAL :
Chimie/Catalyse
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The electronic effects governing the N-arylation of pyrrolidone were investigated. The generalization of our preliminary findings on a copper(I)-catalyzed Csp2-N coupling process was first improved with a wide variety of ...
Lire la suite >The electronic effects governing the N-arylation of pyrrolidone were investigated. The generalization of our preliminary findings on a copper(I)-catalyzed Csp2-N coupling process was first improved with a wide variety of aryl and heteroaryl halides and methyl pyroglutamate. The optimized protocol was further extended to pyrrolidin-2-ones substituted at the C5-position with an aryl group bearing an electron-donating or electron-withdrawing group as well as to some of their substituted enaminoester vinylogues. The impact of substituents at the N- and C5-position on these coupling processes seemed to be pivotal for determining both the reaction profiles and yields.Lire moins >
Lire la suite >The electronic effects governing the N-arylation of pyrrolidone were investigated. The generalization of our preliminary findings on a copper(I)-catalyzed Csp2-N coupling process was first improved with a wide variety of aryl and heteroaryl halides and methyl pyroglutamate. The optimized protocol was further extended to pyrrolidin-2-ones substituted at the C5-position with an aryl group bearing an electron-donating or electron-withdrawing group as well as to some of their substituted enaminoester vinylogues. The impact of substituents at the N- and C5-position on these coupling processes seemed to be pivotal for determining both the reaction profiles and yields.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
ENSCL
CNRS
Inserm
Centrale Lille
Univ. Artois
Université de Lille
ENSCL
CNRS
Inserm
Centrale Lille
Univ. Artois
Université de Lille
Collections :
Équipe(s) de recherche :
Catalyse et chimie supramoléculaire (CASU)
Therapeutic innovation targetting inflammation
Therapeutic innovation targetting inflammation
Date de dépôt :
2019-05-17T13:14:40Z
2021-06-23T06:57:53Z
2021-06-23T06:57:53Z