Titre :

Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure

Auteur(s) :

Pedro Ferreira, João [Auteur]
Universidade do Porto = University of Porto
French-Clinical Research Infrastructure Network - F-CRIN [Paris] [Cardiovascular & Renal Clinical Trialists - CRCT ]
Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] [INI-CRCT]
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] [CIC-P]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]
Verdonschot, Job []
Maastricht University Medical Centre [MUMC]
Cardiovascular Research Institute Maastricht [CARIM]
Collier, Timothy [Auteur]
London School of Hygiene and Tropical Medicine [LSHTM]
Wang, Ping [Auteur]
Maastricht University Medical Centre [MUMC]
Pizard, Anne [Auteur]
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] [CIC-P]
French-Clinical Research Infrastructure Network - F-CRIN [Paris] [Cardiovascular & Renal Clinical Trialists - CRCT ]
Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] [INI-CRCT]
Institut de biologie de l'ENS Paris [IBENS]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]
Bär, Christian [Auteur]
Cleland, John [Auteur]
University of Glasgow
Institute of Health and Wellbeing
Diez, Javier [Auteur]
Institute of Health Carlos III
Center for Applied Medical Research [Plamplona] [CIMA]
Björkman, Jens [Auteur]
Boccanelli, Alessandro [Auteur]
Delles, Christian [Auteur]
Institute of Cardiovascular and Medical Sciences [Glasgow]
Butler, Javed [Auteur]
Medizinische Hochschule Hannover = Hannover Medical School [MHH]
University of Mississippi Medical Center [UMMC]
Clark, Andrew [Auteur]
Girerd, Nicolas [Auteur]
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] [CIC-P]
French-Clinical Research Infrastructure Network - F-CRIN [Paris] [Cardiovascular & Renal Clinical Trialists - CRCT ]
Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] [INI-CRCT]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]
González, Arantxa [Auteur]
Institute of Health Carlos III
Center for Applied Medical Research [Plamplona] [CIMA]
Hazebroek, Mark [Auteur]
Cardiovascular Research Institute Maastricht [CARIM]
Huby, Anne-Cécile [Auteur]
French-Clinical Research Infrastructure Network - F-CRIN [Paris] [Cardiovascular & Renal Clinical Trialists - CRCT ]
Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] [INI-CRCT]
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] [CIC-P]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]
Jukema, Wouter [Auteur]
Leiden University Medical Center [LUMC]
Latini, Roberto [Auteur]
Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research [IRCCS]
Leenders, Joost [Auteur]
Lévy, Daniel [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Framingham Heart Study
Mebazaa, Alexandre [Auteur]
Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Mischak, Harald [Auteur]
Mosaiques Diagnostics and Therapeutics AG [Mosaiques Diagnostics GmbH]
PINET, FLORENCE [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Rossignol, Patrick [Auteur]
French-Clinical Research Infrastructure Network - F-CRIN [Paris] [Cardiovascular & Renal Clinical Trialists - CRCT ]
Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] [INI-CRCT]
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] [CIC-P]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]
Sattar, Naveed [Auteur]
Institute of Cardiovascular and Medical Sciences [Glasgow]
Sever, Peter [Auteur]
Imperial College London
Staessen, Jan [Auteur]
Department of Cardiovascular Sciences [Leuven]
Thum, Thomas [Auteur]
Imperial College London
Vodovar, Nicolas [Auteur]
Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Zhang, Zhen-Yu [Auteur]
Department of Cardiovascular Sciences [Leuven]
Heymans, Stephane []
Department of Cardiovascular Sciences [Leuven]
Cardiovascular Research Institute Maastricht [CARIM]
Zannad, Faiez []
French-Clinical Research Infrastructure Network - F-CRIN [Paris] [Cardiovascular & Renal Clinical Trialists - CRCT ]
Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] [INI-CRCT]
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] [CIC-P]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]

Titre de la revue :

Circulation. Heart failure

Pagination :

e005897

Éditeur :

Lippincott Williams & Wilkins

Date de publication :

2019-05

ISSN :

1941-3289

Mot(s)-clé(s) en anglais :

incident heart failure
proteomics
ageing
prognostic
mechanistic pathways

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire

Résumé en anglais : [en]

Background Identifying the mechanistic pathways potentially associated with incident heart failure (HF) may provide a basis for novel preventive strategies. Methods and Results To identify proteomic biomarkers and the ...
Lire la suite >Background Identifying the mechanistic pathways potentially associated with incident heart failure (HF) may provide a basis for novel preventive strategies. Methods and Results To identify proteomic biomarkers and the potential underlying mechanistic pathways that may be associated with incident HF defined as the first hospitalization for HF, a nested-matched case-control design was used with cases (incident HF) and controls (without HF) selected from 3 cohorts (>20 000 individuals). Controls were matched on cohort, follow-up time, age, and sex. Two independent sample sets (a discovery set with 286 cases and 591 controls and a replication set with 276 cases and 280 controls) were used to discover and replicate the findings. Two hundred fifty-two circulating proteins in the plasma were studied. Adjusting for the matching variables age, sex, and follow-up time (and correcting for multiplicity of tests), 89 proteins were found to be associated with incident HF in the discovery phase, of which 38 were also associated with incident HF in the replication phase. These 38 proteins pointed to 4 main network clusters underlying incident HF: (1) inflammation and apoptosis, indicated by the expression of the TNF (tumor necrosis factor)-family members; (2) extracellular matrix remodeling, angiogenesis and growth, indicated by the expression of proteins associated with collagen metabolism, endothelial function, and vascular homeostasis; (3) blood pressure regulation, indicated by the expression of natriuretic peptides and proteins related to the renin-angiotensin-aldosterone system; and (4) metabolism, associated with cholesterol and atherosclerosis. Conclusions Clusters of biomarkers associated with mechanistic pathways leading to HF were identified linking inflammation, apoptosis, vascular function, matrix remodeling, blood pressure control, and metabolism. These findings provide important insight on the pathophysiological mechanisms leading to HF. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02556450.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Projet ANR :

Isite LUE
Combattre l'insuffisance cardiaque

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL