Global Effect of Modifiable Risk Factors ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
Title :
Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality
Author(s) :
Magnussen, Christina [Auteur]
Ojeda, Francisco [Auteur]
Leong, Darryl [Auteur]
Alegre-Diaz, Jesus [Auteur]
Amouyel, Philippe [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Aviles-Santa, Larissa [Auteur]
de Bacquer, Dirk [Auteur]
Ballantyne, Christie [Auteur]
Bernabé-Ortiz, Antonio [Auteur]
Bobak, Martin [Auteur]
Brenner, Hermann [Auteur]
Carrillo-Larco, Rodrigo [Auteur]
de Lemos, James [Auteur]
Dobson, Annette [Auteur]
Dörr, Marcus [Auteur]
Donfrancesco, Chiara [Auteur]
Drygas, Wojciech [Auteur]
Dullaart, Robin [Auteur]
Engström, Gunnar [Auteur]
Ferrario, Marco [Auteur]
Ferrières, Jean [Auteur]
Service Cardiologie [CHU Toulouse]
Equipe Vieillissement (CERPOP)
de Gaetano, Giovanni [Auteur]
Goldbourt, Uri [Auteur]
Gonzalez, Clicerio [Auteur]
Grassi, Guido [Auteur]
Hodge, Allison [Auteur]
Hveem, Kristian [Auteur]
Iacoviello, Licia [Auteur]
Ikram, M. Kamran [Auteur]
Irazola, Vilma [Auteur]
Jobe, Modou [Auteur]
Jousilahti, Pekka [Auteur]
Kaleebu, Pontiano [Auteur]
Kavousi, Maryam [Auteur]
Kee, Frank [Auteur]
Khalili, Davood [Auteur]
Koenig, Wolfgang [Auteur]
Kontsevaya, Anna [Auteur]
Kuulasmaa, Kari [Auteur]
Lackner, Karl [Auteur]
Leistner, David [Auteur]
Lind, Lars [Auteur]
Linneberg, Allan [Auteur]
Lorenz, Thiess [Auteur]
Lyngbakken, Magnus Nakrem [Auteur]
Malekzadeh, Reza [Auteur]
Malyutina, Sofia [Auteur]
Mathiesen, Ellisiv [Auteur]
Melander, Olle [Auteur]
Metspalu, Andres [Auteur]
Miranda, J. Jaime [Auteur]
Moitry, Marie [Auteur]
Mugisha, Joseph [Auteur]
Nalini, Mahdi [Auteur]
Nambi, Vijay [Auteur]
Ninomiya, Toshiharu [Auteur]
Oppermann, Karen [Auteur]
D’orsi, Eleonora [Auteur]
Pająk, Andrzej [Auteur]
Palmieri, Luigi [Auteur]
Panagiotakos, Demosthenes [Auteur]
Perianayagam, Arokiasamy [Auteur]
Peters, Annette [Auteur]
Poustchi, Hossein [Auteur]
Prentice, Andrew [Auteur]
Prescott, Eva [Auteur]
Risérus, Ulf [Auteur]
Salomaa, Veikko [Auteur]
Sans, Susana [Auteur]
Sakata, Satoko [Auteur]
Schöttker, Ben [Auteur]
Schutte, Aletta [Auteur]
Sepanlou, Sadaf [Auteur]
Sharma, Sanjib Kumar [Auteur]
Shaw, Jonathan [Auteur]
Simons, Leon [Auteur]
Söderberg, Stefan [Auteur]
Tamosiunas, Abdonas [Auteur]
Thorand, Barbara [Auteur]
Tunstall-Pedoe, Hugh [Auteur]
Twerenbold, Raphael [Auteur]
Vanuzzo, Diego [Auteur]
Veronesi, Giovanni [Auteur]
Waibel, Julia [Auteur]
Wannamethee, S. Goya [Auteur]
Watanabe, Masafumi [Auteur]
Wild, Philipp [Auteur]
Yao, Yao [Auteur]
Zeng, Yi [Auteur]
Ziegler, Andreas [Auteur]
Blankenberg, Stefan [Auteur]
Ojeda, Francisco [Auteur]
Leong, Darryl [Auteur]
Alegre-Diaz, Jesus [Auteur]
Amouyel, Philippe [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Aviles-Santa, Larissa [Auteur]
de Bacquer, Dirk [Auteur]
Ballantyne, Christie [Auteur]
Bernabé-Ortiz, Antonio [Auteur]
Bobak, Martin [Auteur]
Brenner, Hermann [Auteur]
Carrillo-Larco, Rodrigo [Auteur]
de Lemos, James [Auteur]
Dobson, Annette [Auteur]
Dörr, Marcus [Auteur]
Donfrancesco, Chiara [Auteur]
Drygas, Wojciech [Auteur]
Dullaart, Robin [Auteur]
Engström, Gunnar [Auteur]
Ferrario, Marco [Auteur]
Ferrières, Jean [Auteur]
Service Cardiologie [CHU Toulouse]
Equipe Vieillissement (CERPOP)
de Gaetano, Giovanni [Auteur]
Goldbourt, Uri [Auteur]
Gonzalez, Clicerio [Auteur]
Grassi, Guido [Auteur]
Hodge, Allison [Auteur]
Hveem, Kristian [Auteur]
Iacoviello, Licia [Auteur]
Ikram, M. Kamran [Auteur]
Irazola, Vilma [Auteur]
Jobe, Modou [Auteur]
Jousilahti, Pekka [Auteur]
Kaleebu, Pontiano [Auteur]
Kavousi, Maryam [Auteur]
Kee, Frank [Auteur]
Khalili, Davood [Auteur]
Koenig, Wolfgang [Auteur]
Kontsevaya, Anna [Auteur]
Kuulasmaa, Kari [Auteur]
Lackner, Karl [Auteur]
Leistner, David [Auteur]
Lind, Lars [Auteur]
Linneberg, Allan [Auteur]
Lorenz, Thiess [Auteur]
Lyngbakken, Magnus Nakrem [Auteur]
Malekzadeh, Reza [Auteur]
Malyutina, Sofia [Auteur]
Mathiesen, Ellisiv [Auteur]
Melander, Olle [Auteur]
Metspalu, Andres [Auteur]
Miranda, J. Jaime [Auteur]
Moitry, Marie [Auteur]
Mugisha, Joseph [Auteur]
Nalini, Mahdi [Auteur]
Nambi, Vijay [Auteur]
Ninomiya, Toshiharu [Auteur]
Oppermann, Karen [Auteur]
D’orsi, Eleonora [Auteur]
Pająk, Andrzej [Auteur]
Palmieri, Luigi [Auteur]
Panagiotakos, Demosthenes [Auteur]
Perianayagam, Arokiasamy [Auteur]
Peters, Annette [Auteur]
Poustchi, Hossein [Auteur]
Prentice, Andrew [Auteur]
Prescott, Eva [Auteur]
Risérus, Ulf [Auteur]
Salomaa, Veikko [Auteur]
Sans, Susana [Auteur]
Sakata, Satoko [Auteur]
Schöttker, Ben [Auteur]
Schutte, Aletta [Auteur]
Sepanlou, Sadaf [Auteur]
Sharma, Sanjib Kumar [Auteur]
Shaw, Jonathan [Auteur]
Simons, Leon [Auteur]
Söderberg, Stefan [Auteur]
Tamosiunas, Abdonas [Auteur]
Thorand, Barbara [Auteur]
Tunstall-Pedoe, Hugh [Auteur]
Twerenbold, Raphael [Auteur]
Vanuzzo, Diego [Auteur]
Veronesi, Giovanni [Auteur]
Waibel, Julia [Auteur]
Wannamethee, S. Goya [Auteur]
Watanabe, Masafumi [Auteur]
Wild, Philipp [Auteur]
Yao, Yao [Auteur]
Zeng, Yi [Auteur]
Ziegler, Andreas [Auteur]
Blankenberg, Stefan [Auteur]
Journal title :
New England Journal of Medicine
Pages :
1273-1285
Publisher :
Massachusetts Medical Society
Publication date :
2023-10-05
ISSN :
0028-4793
HAL domain(s) :
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Santé publique et épidémiologie
Sciences du Vivant [q-bio]/Santé publique et épidémiologie
English abstract : [en]
Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and ...
Show more >Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).Show less >
Show more >Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Collections :
Source :
Files
- nejmoa2206916.pdf
- Open access
- Access the document