Titre :

Association of the Polygenic Risk Score With the Probability of Prodromal Parkinson’s Disease in Older Adults

Auteur(s) :

Maraki, Maria [Auteur]
Hatzimanolis, Alexandros [Auteur]
Mourtzi, Niki [Auteur]
Stefanis, Leonidas [Auteur]
Yannakoulia, Mary [Auteur]
Kosmidis, Mary [Auteur]
Dardiotis, Efthimios [Auteur]
Hadjigeorgiou, Georgios [Auteur]
Sakka, Paraskevi [Auteur]
Ramirez, Alfredo [Auteur]
Grenier-Boley, Benjamin [Auteur]
Lambert, Jean-Charles [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Heilmann-Heimbach, Stefanie [Auteur]
Stamelou, Maria [Auteur]
Scarmeas, Nikolaos [Auteur]
Xiromerisiou, Georgia [Auteur]

Titre de la revue :

Frontiers in Molecular Neuroscience

Pagination :

4

Éditeur :

Frontiers Media

Date de publication :

2021-12-21

ISSN :

1662-5099

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Several studies have investigated the association of the Parkinson’s disease (PD) polygenic risk score (PRS) with several aspects of well-established PD. We sought to evaluate the association of PRS with the prodromal stage ...
Lire la suite >Several studies have investigated the association of the Parkinson’s disease (PD) polygenic risk score (PRS) with several aspects of well-established PD. We sought to evaluate the association of PRS with the prodromal stage of PD. We calculated PRS in a longitudinal sample ( n = 1120) of community dwelling individuals ≥ 65 years from the HELIAD (The Hellenic Longitudinal Investigation of Aging and Diet) study in order to evaluate the association of this score with the probability of prodromal PD or any of the established risk and prodromal markers in MDS research criteria, using regression multi-adjusted models. Increases in PRS estimated from GWAS summary statistics’ ninety top SNPS with p < 5 × 10 –8 was associated with increased odds of having probable/possible prodromal PD (i.e., ≥ 30% probability, OR = 1.033, 95%CI: 1.009–1.057 p = 0.006). From the prodromal PD risk markers, significant association was found between PRS and global cognitive deficit exclusively ( p = 0.003). To our knowledge, our study is the first population based study investigating the association between PRS scores and prodromal markers of Parkinson’s disease. Our results suggest a strong relationship between the accumulation of many common genetic variants, as measured by PRS, and cognitive deficits.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Projet ANR :

Développement de stratégies innovantes pour une approche transdisciplinaire de la maladie d'Alzheime

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL