Titre :

Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice.

Auteur(s) :

Djouina, Madjid [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Vignal, Cecile [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dehaut, A. [Auteur]
Caboche, Segolene [Auteur]
Genomic @ Lille - PLBS [GO@L]
Hirt, Nell [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Waxin, Christophe [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Himber, C. [Auteur]
Beury, Delphine [Auteur]
Genomic @ Lille - PLBS [GO@L]
Hot, David [Auteur]
Genomic @ Lille - PLBS [GO@L]
Dubuquoy, Laurent [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Launay, David [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Duflos, G. [Auteur]
Body-Malapel, Mathilde [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Titre de la revue :

Environmental Research

Nom court de la revue :

Environ Res

Numéro :

212

Pagination :

113230

Date de publication :

2022

ISSN :

1096-0953

Mot(s)-clé(s) en anglais :

Microplastics
inflammation
polyethylene
mice
intestinal
microbiota

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

The ubiquitous and growing presence of microplastics (MPs) in all compartments of the environment raises concerns about their possible harmful effects on human health. Human exposure to MPs occurs largely through ingestion. ...
Lire la suite >The ubiquitous and growing presence of microplastics (MPs) in all compartments of the environment raises concerns about their possible harmful effects on human health. Human exposure to MPs occurs largely through ingestion. Polyethylene (PE) is widely employed for reusable bags and food packaging and found to be present in drinking water and food. It is also one of the major polymers detected in human stool. The aim of this study was to characterize the effects of intestinal exposure to PE MPs on gut homeostasis. Mice were orally exposed for 6 weeks to PE microbeads of 2 different sizes, 36 and 116 μm, that correspond to those found in human stool. They were administrated either individually or as a mixture at a dose of 100 μg/g of food. Both PE microbead sizes were detected in mouse stool. Different parameters related to major intestinal functions were compared between control mice, mice exposed to each type of microbead, or co-exposed to the 2 types of microbeads. Intestinal disturbances were observed after individual exposure to each size of PE microbead, and the most marked deleterious effects were found in co-exposed mice. At the histomorphological level, crypt depth was increased throughout the intestinal tissues. Significant variations of gene expression related to epithelial, permeability, and inflammatory biomarkers were quantified. Defective recruitment of some intestinal immune cells was observed from the proximal portion of the small intestine to the colon. Several bacterial taxa at the order level were found to be affected by exposure to the MPs by metagenomic analysis of cecal microbiota. These results show that ingestion of PE microbeads induces significant alterations of crucial intestinal markers in mice and underscores the need to further study the health impact of MP exposure in humans.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41

Équipe(s) de recherche :

Genomic @ Lille (GO@L)

Date de dépôt :

2023-12-21T06:53:24Z
2024-02-07T12:17:29Z
2024-02-28T08:01:20Z