CD27 is required for protective lytic EBV ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Title :
CD27 is required for protective lytic EBV antigen-specific CD8(+) T-cell expansion
Author(s) :
Deng, Y. [Auteur]
Chatterjee, B. [Auteur]
Zens, K. [Auteur]
Zdimerova, H. [Auteur]
Muller, A. [Auteur]
Schuhmachers, P. [Auteur]
Ligeon, L. A. [Auteur]
Bongiovanni, Antonino [Auteur]
Plateforme BioImaging Center Lille - PLBS [BICeL]
Capaul, R. [Auteur]
Zbinden, A. [Auteur]
Holler, A. [Auteur]
Stauss, H. [Auteur]
Hammerschmidt, W. [Auteur]
Munz, C. [Auteur]
Chatterjee, B. [Auteur]
Zens, K. [Auteur]
Zdimerova, H. [Auteur]
Muller, A. [Auteur]
Schuhmachers, P. [Auteur]
Ligeon, L. A. [Auteur]
Bongiovanni, Antonino [Auteur]
Plateforme BioImaging Center Lille - PLBS [BICeL]
Capaul, R. [Auteur]
Zbinden, A. [Auteur]
Holler, A. [Auteur]
Stauss, H. [Auteur]
Hammerschmidt, W. [Auteur]
Munz, C. [Auteur]
Journal title :
Blood
Abbreviated title :
Blood
Volume number :
137
Pages :
3225–3236
Publication date :
2021
ISSN :
0006-4971
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both ...
Show more >Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and antibody blocking of CD27 interaction with CD70 cause uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T-cell expansion and composition are unaltered after antibody blocking of CD27, only some EBV-specific CD8+ T-cell responses, exemplified by early lytic EBV antigen BMLF1-specific CD8+ T cells, are inhibited in their proliferation and killing of EBV-transformed B cells. This suggests that CD27 is not required for all CD8+ T-cell expansions and cytotoxicity but is required for a subset of CD8+ T-cell responses that protect us from EBV pathology.Show less >
Show more >Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and antibody blocking of CD27 interaction with CD70 cause uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T-cell expansion and composition are unaltered after antibody blocking of CD27, only some EBV-specific CD8+ T-cell responses, exemplified by early lytic EBV antigen BMLF1-specific CD8+ T cells, are inhibited in their proliferation and killing of EBV-transformed B cells. This suggests that CD27 is not required for all CD8+ T-cell expansions and cytotoxicity but is required for a subset of CD8+ T-cell responses that protect us from EBV pathology.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Research team(s) :
Plateforme BioImaging Center Lille (BICeL)
Submission date :
2023-12-21T07:13:31Z
2024-02-23T21:33:27Z
2024-02-23T21:33:27Z