Titre :

CD27 is required for protective lytic EBV antigen-specific CD8(+) T-cell expansion

Auteur(s) :

Deng, Y. [Auteur]
Chatterjee, B. [Auteur]
Zens, K. [Auteur]
Zdimerova, H. [Auteur]
Muller, A. [Auteur]
Schuhmachers, P. [Auteur]
Ligeon, L. A. [Auteur]
Bongiovanni, Antonino [Auteur]
Plateforme BioImaging Center Lille - PLBS [BICeL]
Capaul, R. [Auteur]
Zbinden, A. [Auteur]
Holler, A. [Auteur]
Stauss, H. [Auteur]
Hammerschmidt, W. [Auteur]
Munz, C. [Auteur]

Titre de la revue :

Blood

Nom court de la revue :

Blood

Numéro :

137

Pagination :

3225–3236

Date de publication :

2021

ISSN :

0006-4971

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both ...
Lire la suite >Primary immunodeficiencies in the costimulatory molecule CD27 and its ligand, CD70, predispose for pathologies of uncontrolled Epstein-Barr virus (EBV) infection in nearly all affected patients. We demonstrate that both depletion of CD27+ cells and antibody blocking of CD27 interaction with CD70 cause uncontrolled EBV infection in mice with reconstituted human immune system components. While overall CD8+ T-cell expansion and composition are unaltered after antibody blocking of CD27, only some EBV-specific CD8+ T-cell responses, exemplified by early lytic EBV antigen BMLF1-specific CD8+ T cells, are inhibited in their proliferation and killing of EBV-transformed B cells. This suggests that CD27 is not required for all CD8+ T-cell expansions and cytotoxicity but is required for a subset of CD8+ T-cell responses that protect us from EBV pathology.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41

Équipe(s) de recherche :

Plateforme BioImaging Center Lille (BICeL)

Date de dépôt :

2023-12-21T07:13:31Z
2024-02-23T21:33:27Z