Beneficial effects of atorvastatin on ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
Permalink :
Title :
Beneficial effects of atorvastatin on sex-specific cognitive impairment induced by a cerebral microhaemorrhage in a murine model.
Author(s) :
Bergeron, Sandrine [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Barus, Romain [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Leboullenger, Clemence [Auteur]
Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41
Lille in vivo imaging and Functional Exploration - PLBS [LiiFE]
Auger, Florent [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Bongiovanni, Antonino [Auteur]
Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41
Plateforme BioImaging Center Lille - PLBS [BICeL]
Tardivel, Meryem [Auteur]
Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41
Plateforme BioImaging Center Lille - PLBS [BICeL]
Jonneaux, Aurelie [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
LALOUX, Charlotte [Auteur]
Potey, Camille [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Bordet, Regis [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Chen, Yaohua [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
GAUTIER, Sophie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Barus, Romain [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Leboullenger, Clemence [Auteur]
Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41
Lille in vivo imaging and Functional Exploration - PLBS [LiiFE]
Auger, Florent [Auteur]

Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Bongiovanni, Antonino [Auteur]
Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41
Plateforme BioImaging Center Lille - PLBS [BICeL]
Tardivel, Meryem [Auteur]

Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41
Plateforme BioImaging Center Lille - PLBS [BICeL]
Jonneaux, Aurelie [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
LALOUX, Charlotte [Auteur]
Potey, Camille [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Bordet, Regis [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Chen, Yaohua [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
GAUTIER, Sophie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Journal title :
British Journal of Pharmacology
Abbreviated title :
Br J Pharmacol
Volume number :
178
Pages :
p. 1705-1721
Publication date :
2021-04
ISSN :
1476-5381
English keyword(s) :
cerebral microhaemorrhage
cognition
FDG PET
mice
microglia
sex
statin
cognition
FDG PET
mice
microglia
sex
statin
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background and Purposes
Cerebral microhaemorrhages (CMHs) are associated with cognitive decline in humans. In rodents, CMHs induces cognitive impairment in male mice along with sex-specific cortical and hippocampal ...
Show more >Background and Purposes Cerebral microhaemorrhages (CMHs) are associated with cognitive decline in humans. In rodents, CMHs induces cognitive impairment in male mice along with sex-specific cortical and hippocampal changes affecting neural, glial and vascular functions. Statins, have been proposed to prevent cognitive decline. We tested here the action of atorvastatin on CMH-induced cognitive impairment in a murine model of CMH. Experimental Approach Using a multimodal approach combining behavioural tests, in vivo imaging, biochemistry and molecular biology, the effects of oral administration of atorvastatin on the sex-specific changes induced by a cortical CMH were studied in male and female mice (C57BL/6J) at 6-week post-induction using a collagenase-induced model. Key Results Atorvastatin caused specific effects according to the sex-specific CMH-induced changes. In males, atorvastatin improved the visuospatial memory, induced a local modulation of microglial response and enhanced brain-derived neurotrophic factor (BDNF)-tropomyosin receptor kinase B (trkB) and vascular endothelial growth factor (VEGF) expression in the cortex. In the hippocampus, atorvastatin increased glucose metabolism and modulated astrocytes morphology. In females, atorvastatin did not modulate visuospatial memory despite the increased expression of cortical BDNF and the decrease in the number of hippocampal astrocytes. Atorvastatin also induced a decrease in the expression of cortical oestrogen receptors but did not modify body weight nor serum cholesterol levels in both sexes. Conclusion and Implications Atorvastatin modulated the sex-specific cognitive impairment induced by the CMH with a pathophysiological impact mainly within the cortical area. It could represent a promising candidate for future sex-stratified clinical trials in patients with CMH.Show less >
Show more >Background and Purposes Cerebral microhaemorrhages (CMHs) are associated with cognitive decline in humans. In rodents, CMHs induces cognitive impairment in male mice along with sex-specific cortical and hippocampal changes affecting neural, glial and vascular functions. Statins, have been proposed to prevent cognitive decline. We tested here the action of atorvastatin on CMH-induced cognitive impairment in a murine model of CMH. Experimental Approach Using a multimodal approach combining behavioural tests, in vivo imaging, biochemistry and molecular biology, the effects of oral administration of atorvastatin on the sex-specific changes induced by a cortical CMH were studied in male and female mice (C57BL/6J) at 6-week post-induction using a collagenase-induced model. Key Results Atorvastatin caused specific effects according to the sex-specific CMH-induced changes. In males, atorvastatin improved the visuospatial memory, induced a local modulation of microglial response and enhanced brain-derived neurotrophic factor (BDNF)-tropomyosin receptor kinase B (trkB) and vascular endothelial growth factor (VEGF) expression in the cortex. In the hippocampus, atorvastatin increased glucose metabolism and modulated astrocytes morphology. In females, atorvastatin did not modulate visuospatial memory despite the increased expression of cortical BDNF and the decrease in the number of hippocampal astrocytes. Atorvastatin also induced a decrease in the expression of cortical oestrogen receptors but did not modify body weight nor serum cholesterol levels in both sexes. Conclusion and Implications Atorvastatin modulated the sex-specific cognitive impairment induced by the CMH with a pathophysiological impact mainly within the cortical area. It could represent a promising candidate for future sex-stratified clinical trials in patients with CMH.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Collections :
Submission date :
2023-12-21T07:15:00Z
2024-01-30T09:07:03Z
2024-02-14T16:25:41Z
2024-01-30T09:07:03Z
2024-02-14T16:25:41Z
Files
- British J Pharmacology - 2021 - Bergeron - Beneficial effects of atorvastatin on sex‐specific cognitive impairment induced.pdf
- Version éditeur
- Restricted access
- Access the document