Title :

Transcriptomic signatures of brain regional vulnerability to Parkinson's disease.

Author(s) :

Keo, A. [Auteur]
Mahfouz, A. [Auteur]
Ingrassia, A. M. T. [Auteur]
Meneboo, Jean-Pascal [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Plateforme de bioinformatique et de biostatistique de Lille - PLBS [Bilille]
Villenet, Celine [Auteur]
Plateforme de génomique fonctionnelle et structurelle [Lille]
Genomic @ Lille - PLBS [GO@L]
Mutez, Eugenie [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Comptdaer, Thomas [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Lelieveldt, B. P. F. [Auteur]
Figeac, Martin [Auteur]
Genomic @ Lille - PLBS [GO@L]
Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41
Chartier-Harlin, Marie-Christine [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Van De Berg, W. D. J. [Auteur]
Van Hilten, J. J. [Auteur]
Reinders, M. J. T. [Auteur]

Journal title :

Communications Biology

Abbreviated title :

Commun Biol

Volume number :

3

Pages :

101

Publication date :

2020-03-05

ISSN :

2399-3642

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Abstract The molecular mechanisms underlying caudal-to-rostral progression of Lewy body pathology in Parkinson’s disease remain poorly understood. Here, we identified transcriptomic signatures across brain regions involved ...
Show more >Abstract The molecular mechanisms underlying caudal-to-rostral progression of Lewy body pathology in Parkinson’s disease remain poorly understood. Here, we identified transcriptomic signatures across brain regions involved in Braak Lewy body stages in non-neurological adults from the Allen Human Brain Atlas. Among the genes that are indicative of regional vulnerability, we found known genetic risk factors for Parkinson’s disease: SCARB2 , ELOVL7, SH3GL2 , SNCA , BAP1 , and ZNF184 . Results were confirmed in two datasets of non-neurological subjects, while in two datasets of Parkinson’s disease patients we found altered expression patterns. Co-expression analysis across vulnerable regions identified a module enriched for genes associated with dopamine synthesis and microglia, and another module related to the immune system, blood-oxygen transport, and endothelial cells. Both were highly expressed in regions involved in the preclinical stages of the disease. Finally, alterations in genes underlying these region-specific functions may contribute to the selective regional vulnerability in Parkinson’s disease brains.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172
• Plateformes Lilloises en Biologie et Santé (PLBS) - UAR 2014 - US 41

Submission date :

2023-12-21T07:23:11Z
2024-01-24T12:59:44Z
2024-01-24T14:22:29Z