Title :

An immunologically relevant rodent model demonstrates safety of therapy using a tumour‐specific IgE

Author(s) :

Dombrowicz, David [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]

Journal title :

Allergy

Pages :

2328 - 2341

Publisher :

Wiley

Publication date :

2018-10-08

ISSN :

0105-4538

English keyword(s) :

AllergoOncology cancer IgE immunotherapy rat
AllergoOncology
cancer
IgE
immunotherapy
rat

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: Designing biologically informative models for assessing the safety of novel agents, especially for cancer immunotherapy, carries substantial challenges. The choice of an in vivo system for studies on IgE ...
Show more >Background: Designing biologically informative models for assessing the safety of novel agents, especially for cancer immunotherapy, carries substantial challenges. The choice of an in vivo system for studies on IgE antibodies represents a major impediment to their clinical translation, especially with respect to class-specific immunological functions and safety. Fce receptor expression and structure are different in humans and mice, so that the murine system is not informative when studying human IgE biology. By contrast, FceRI expression and cellular distribution in rats mirror that of humans. Josephs and Nakamura equally contributed to this work.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL