Titre :

LIPCAR Is Increased in Chronic Symptomatic HF Patients. A Sub-Study of the GISSI-HF Trial

Auteur(s) :

Meessen, Jennifer [Auteur]
Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research [IRCCS]
Bär, Christian [Auteur]
Medizinische Hochschule Hannover = Hannover Medical School [MHH]
Di Dona, Filippo [Auteur]
Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research [IRCCS]
Staszewsky, Lidia [Auteur]
Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research [IRCCS]
Di Giulio, Paola [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Di Tano, Giuseppe [Auteur]
Costa, Alessia [Auteur]
Medizinische Hochschule Hannover = Hannover Medical School [MHH]
Leonardy, Julia [Auteur]
Medizinische Hochschule Hannover = Hannover Medical School [MHH]
Novelli, Deborah [Auteur]
Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research [IRCCS]
Nicolis, Enrico [Auteur]
Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research [IRCCS]
Masson, Serge [Auteur]
Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research [IRCCS]
PINET, FLORENCE [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Thum, Thomas [Auteur]
Medizinische Hochschule Hannover = Hannover Medical School [MHH]
Latini, Roberto [Auteur]
Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research [IRCCS]

Titre de la revue :

Clinical chemistry

Pagination :

1721-1731

Éditeur :

American Association for Clinical Chemistry

Date de publication :

2021-12-01

ISSN :

0009-9147

Mot(s)-clé(s) en anglais :

LIPCAR
NYHA class
biomarker
cardiovascular hospitalization
eGFR
heart failure
long noncoding RNA

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie

Résumé en anglais : [en]

Abstract Background The long noncoding RNA LIPCAR (Long Intergenic noncoding RNA Predicting CARdiac remodeling) has emerged as a promising biomarker in cardiac disease and cardiac remodeling. To determine whether LIPCAR ...
Lire la suite >Abstract Background The long noncoding RNA LIPCAR (Long Intergenic noncoding RNA Predicting CARdiac remodeling) has emerged as a promising biomarker in cardiac disease and cardiac remodeling. To determine whether LIPCAR levels help for a molecular phenotyping of chronic heart failure (HF) patients, this study assessed the association of LIPCAR with severity of the disease and its progression, and with risk of death or hospitalization in HF patients. Methods LIPCAR was measured in plasma of 967 HF patients with symptomatic heart failure participating in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca - Heart Failure (GISSI-HF) biohumoral sub-study. Results Plasma levels of LIPCAR were significantly associated with functional impairment as assessed by the New York Heart Association (NYHA) class, kidney function as reflected by estimated glomerular filtration rate, and creatinine, hemoglobin and mitral insufficiency. In females, these associations were more marked as compared to males. LIPCAR plasma levels were significantly related to the two cardiac markers, N-terminal pro-B type natriuretic peptide and high-sensitivity cardiac troponin T, but not to inflammatory markers such as high sensitivity C-reactive protein and pentraxin-3, nor to patient reported outcomes such as depression and quality of life. HF patients with high LIPCAR levels univariately showed significantly higher incidence of cardiovascular hospitalizations but not of death; after adjusting for covariates, no significant effects of LIPCAR were found for cardiovascular hospitalizations. Conclusion The circulating long noncoding RNA LIPCAR was increased in HF patients with higher NYHA class, impaired kidney function, and lower hemoglobin, which are indicators of patients’ overall state.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Projet ANR :

LIPCAR, a prognostic marker of heart failure with reduced ejection fraction

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL