Energetic dysfunction in sepsis: a narrative ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Title :
Energetic dysfunction in sepsis: a narrative review
Author(s) :
Preau, Sebastien [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Vodovar, Dominique [Auteur]
UFR Médecine [Santé] - Université Paris Cité [UFR Médecine UPCité]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
Hôpital Lariboisière-Fernand-Widal [APHP]
Jung, Boris [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Lancel, Steve [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Zafrani, Lara [Auteur]
Immunologie humaine, physiopathologie & immunothérapie [HIPI (UMR_S_976 / U976)]
Hopital Saint-Louis [AP-HP] [AP-HP]
Flatres, Aurelien [Auteur]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Oualha, Mehdi [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Voiriot, Guillaume [Auteur]
Sorbonne Université [SU]
CHU Tenon [AP-HP]
Jouan, Youenn [Auteur]
Pathologies Respiratoires : Protéolyse et Aérosolthérapie [PRPA]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Joffre, Jeremie [Auteur]
Système immunitaire et neuroinflammation [CRSA]
Centre de Recherche Saint-Antoine [CRSA]
University of California [San Francisco] [UC San Francisco]
Huel, Fabrice [Auteur]
Hôpital Louis Mourier - AP-HP [Colombes]
de Prost, Nicolas [Auteur]
Hôpital Henri Mondor
Silva, Stein [Auteur]
Toulouse NeuroImaging Center [ToNIC]
Azabou, Eric [Auteur]
Hôpital Raymond Poincaré [AP-HP]
UFR Sciences de la santé Simone Veil [UVSQ Santé]
Infection et inflammation [2I]
Radermacher, Peter [Auteur]
Universitätsklinikum Ulm - University Hospital of Ulm

Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Vodovar, Dominique [Auteur]
UFR Médecine [Santé] - Université Paris Cité [UFR Médecine UPCité]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
Hôpital Lariboisière-Fernand-Widal [APHP]
Jung, Boris [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Lancel, Steve [Auteur]

Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Zafrani, Lara [Auteur]
Immunologie humaine, physiopathologie & immunothérapie [HIPI (UMR_S_976 / U976)]
Hopital Saint-Louis [AP-HP] [AP-HP]
Flatres, Aurelien [Auteur]
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] [PhyMedExp]
Oualha, Mehdi [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Voiriot, Guillaume [Auteur]
Sorbonne Université [SU]
CHU Tenon [AP-HP]
Jouan, Youenn [Auteur]
Pathologies Respiratoires : Protéolyse et Aérosolthérapie [PRPA]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Joffre, Jeremie [Auteur]
Système immunitaire et neuroinflammation [CRSA]
Centre de Recherche Saint-Antoine [CRSA]
University of California [San Francisco] [UC San Francisco]
Huel, Fabrice [Auteur]
Hôpital Louis Mourier - AP-HP [Colombes]
de Prost, Nicolas [Auteur]
Hôpital Henri Mondor
Silva, Stein [Auteur]
Toulouse NeuroImaging Center [ToNIC]
Azabou, Eric [Auteur]
Hôpital Raymond Poincaré [AP-HP]
UFR Sciences de la santé Simone Veil [UVSQ Santé]
Infection et inflammation [2I]
Radermacher, Peter [Auteur]
Universitätsklinikum Ulm - University Hospital of Ulm
Journal title :
Annals of Intensive Care
Publisher :
SpringerOpen
Publication date :
2021-12
ISSN :
2110-5820
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background Growing evidence associates organ dysfunction(s) with impaired metabolism in sepsis. Recent research has increased our understanding of the role of substrate utilization and mitochondrial dysfunction in the ...
Show more >Background Growing evidence associates organ dysfunction(s) with impaired metabolism in sepsis. Recent research has increased our understanding of the role of substrate utilization and mitochondrial dysfunction in the pathophysiology of sepsis-related organ dysfunction. The purpose of this review is to present this evidence as a coherent whole and to highlight future research directions. Main text Sepsis is characterized by systemic and organ-specific changes in metabolism. Alterations of oxygen consumption, increased levels of circulating substrates, impaired glucose and lipid oxidation, and mitochondrial dysfunction are all associated with organ dysfunction and poor outcomes in both animal models and patients. The pathophysiological relevance of bioenergetics and metabolism in the specific examples of sepsis-related immunodeficiency, cerebral dysfunction, cardiomyopathy, acute kidney injury and diaphragmatic failure is also described. Conclusions Recent understandings in substrate utilization and mitochondrial dysfunction may pave the way for new diagnostic and therapeutic approaches. These findings could help physicians to identify distinct subgroups of sepsis and to develop personalized treatment strategies. Implications for their use as bioenergetic targets to identify metabolism- and mitochondria-targeted treatments need to be evaluated in future studies.Show less >
Show more >Background Growing evidence associates organ dysfunction(s) with impaired metabolism in sepsis. Recent research has increased our understanding of the role of substrate utilization and mitochondrial dysfunction in the pathophysiology of sepsis-related organ dysfunction. The purpose of this review is to present this evidence as a coherent whole and to highlight future research directions. Main text Sepsis is characterized by systemic and organ-specific changes in metabolism. Alterations of oxygen consumption, increased levels of circulating substrates, impaired glucose and lipid oxidation, and mitochondrial dysfunction are all associated with organ dysfunction and poor outcomes in both animal models and patients. The pathophysiological relevance of bioenergetics and metabolism in the specific examples of sepsis-related immunodeficiency, cerebral dysfunction, cardiomyopathy, acute kidney injury and diaphragmatic failure is also described. Conclusions Recent understandings in substrate utilization and mitochondrial dysfunction may pave the way for new diagnostic and therapeutic approaches. These findings could help physicians to identify distinct subgroups of sepsis and to develop personalized treatment strategies. Implications for their use as bioenergetic targets to identify metabolism- and mitochondria-targeted treatments need to be evaluated in future studies.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
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