Title :

Echocardiographic diastolic function evolution in patients with an anterior Q-wave myocardial infarction: insights from the REVE-2 study.

Author(s) :

Ferreira, Joao Pedro [Auteur]
Centre d'investigation clinique [Nancy] [CIC]
Bauters, Christophe [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Eschalier, Romain [Auteur]
Centre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
Lamiral, Zohra [Auteur]
Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] [CIC-P]
Fay, Renaud [Auteur]
Service de Médecine Nucléaire [CHRU Nancy]
Huttin, Olivier [Auteur]
Centre d'investigation clinique - Epidémiologie clinique [Nancy] [CIC-EC]
Girerd, Nicolas [Auteur]
Centre d'investigation clinique [Nancy] [CIC]
Zannad, Faiez [Auteur]
Centre d'investigation clinique [Nancy] [CIC]
PINET, FLORENCE [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Rossignol, Patrick [Auteur]
Centre d'investigation clinique [Nancy] [CIC]

Journal title :

ESC heart failure

Pages :

70-79

Publisher :

Wiley

Publication date :

2018-11-20

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire

English abstract : [en]

Background: Myocardial fibrosis plays a key role in the development of adverse left ventricular remodeling after myocardial infarction (MI). This study aimed to determine whether the circulating levels of BNP, collagen ...
Show more >Background: Myocardial fibrosis plays a key role in the development of adverse left ventricular remodeling after myocardial infarction (MI). This study aimed to determine whether the circulating levels of BNP, collagen peptides, and galectin-3 are associated with diastolic function evolution (both deterioration and improvement) at 1-year after an anterior MI.Methods: The REVE-2 is a prospective multicenter study including 246 patients with a first anterior Q-wave MI. Echocardiographic assessment was performed at hospital discharge and ±1-year after MI. BNP, Galectin-3 and collagen peptides were measured ±1-month after MI. Left ventricular diastolic dysfunction (DD) was defined according to the presence of at least 2 criteria of echocardiographic parameters: septal e’<8 cm/s, lateral e’<10 cm/s and left atrial volume ≥34 mL/m2.Results: At baseline 87 (35.4%) patients had normal diastolic function and 159 (64.6%) patients had diastolic dysfunction. Follow-up of 61 patients among the 87 patients with normal diastolic function at baseline showed that 22 patients (36%) developed DD at 1-year post-MI. The circulating levels of PIIINP>6 mg/l (Odds Ratio, OR=5.29; 95%CI=1.05-26.66; p=0.044), Galectin-3>13 μg/l (OR=5.99; 95%CI=1.18-30.45; p=0.031), and BNP>82 ng/l (OR=10.25; 95%CI=2.36-44.50; p=0.002) quantified at 1-month post-MI were independently associated with 1-year DD. Follow-up of the 137 patients with DD at baseline among the 159 patients showed that 36 patients (26%) had a normalized diastolic function at 1-year post-MI. Patients with a BNP>82 ng/l were less likely to improve diastolic function (OR=0.06; 95%CI=0.01-0.28; p=0.0003).Conclusions. The present study suggests that circulating levels of PIIINP, Galectin-3 and BNP may be independently associated with new-onset DD in post-MI patients.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Nouveaux Biomarqueurs Pronostiques de prédiction de mortalité cardiaque précoce des Patients Insuffisants Cardiaques : Apport de la protéomique
Combattre l'insuffisance cardiaque

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL