Pulmonary Embolism and Deep Vein Thrombosis ...
Document type :
Article dans une revue scientifique: Article original
Title :
Pulmonary Embolism and Deep Vein Thrombosis in COVID-19: A Systematic Review and Meta-Analysis
Author(s) :
Suh, Young Joo [Auteur]
Hong, Hyunsook [Auteur]
Ohana, Mickaël [Auteur]
Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie [ICube]
Bompard, Florian [Auteur]
Hôpital Cochin [AP-HP]
Revel, Marie-Pierre [Auteur]
Hôpital Cochin [AP-HP]
Valle, Clarissa [Auteur]
Gervaise, Alban [Auteur]
Poissy, Julien [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Susen, Sophie [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Hekimian, Guillaume [Auteur]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Artifoni, Mathieu [Auteur]
Periard, Daniel [Auteur]
Contou, Damien [Auteur]
Delaloye, Julie [Auteur]
Sanchez, Bienvenido [Auteur]
Fang, Cheng [Auteur]
Garzillo, Giorgio [Auteur]
Robbie, Hasti [Auteur]
Yoon, Soon Ho [Auteur]
Hong, Hyunsook [Auteur]
Ohana, Mickaël [Auteur]
Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie [ICube]
Bompard, Florian [Auteur]
Hôpital Cochin [AP-HP]
Revel, Marie-Pierre [Auteur]
Hôpital Cochin [AP-HP]
Valle, Clarissa [Auteur]
Gervaise, Alban [Auteur]
Poissy, Julien [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Susen, Sophie [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Hekimian, Guillaume [Auteur]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Artifoni, Mathieu [Auteur]
Periard, Daniel [Auteur]
Contou, Damien [Auteur]
Delaloye, Julie [Auteur]
Sanchez, Bienvenido [Auteur]
Fang, Cheng [Auteur]
Garzillo, Giorgio [Auteur]
Robbie, Hasti [Auteur]
Yoon, Soon Ho [Auteur]
Journal title :
Radiology
Pages :
E70-E80
Publisher :
Radiological Society of North America
Publication date :
2021
ISSN :
0033-8419
HAL domain(s) :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies émergentes
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Pneumologie et système respiratoire
Sciences du Vivant [q-bio]/Santé publique et épidémiologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies émergentes
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Pneumologie et système respiratoire
Sciences du Vivant [q-bio]/Santé publique et épidémiologie
English abstract : [en]
Background:The association of pulmonary embolism (PE) with deep vein thrombosis (DVT) in patients with coronavirus disease 2019 (COVID-19) remains unclear, and the diagnostic accuracy of D-dimer tests for PE is unknown.Purpose:To ...
Show more >Background:The association of pulmonary embolism (PE) with deep vein thrombosis (DVT) in patients with coronavirus disease 2019 (COVID-19) remains unclear, and the diagnostic accuracy of D-dimer tests for PE is unknown.Purpose:To conduct a meta-analysis of the study-level incidence of PE and DVT and to evaluate the diagnostic accuracy of D-dimer tests for PE from multicenter individual patient data.Materials and Methods:A systematic literature search identified studies evaluating the incidence of PE or DVT in patients with COVID-19 from January 1, 2020, to June 15, 2020. These outcomes were pooled using a random-effects model and were further evaluated using metaregression analysis. The diagnostic accuracy of D-dimer tests for PE was estimated based on individual patient data using the summary receiver operating characteristic curve.Results:Twenty-seven studies with 3342 patients with COVID-19 were included in the analysis. The pooled incidence rates of PE and DVT were 16.5% (95% CI: 11.6, 22.9; I2 = 0.93) and 14.8% (95% CI: 8.5, 24.5; I2 = 0.94), respectively. PE was more frequently found in patients who were admitted to the intensive care unit (ICU) (24.7% [95% CI: 18.6, 32.1] vs 10.5% [95% CI: 5.1, 20.2] in those not admitted to the ICU) and in studies with universal screening using CT pulmonary angiography. DVT was present in 42.4% of patients with PE. D-dimer tests had an area under the receiver operating characteristic curve of 0.737 for PE, and D-dimer levels of 500 and 1000 μg/L showed high sensitivity (96% and 91%, respectively) but low specificity (10% and 24%, respectively).Conclusion:Pulmonary embolism (PE) and deep vein thrombosis (DVT) occurred in 16.5% and 14.8% of patients with coronavirus disease 2019 (COVID-19), respectively, and more than half of patients with PE lacked DVT. The cutoffs of D-dimer levels used to exclude PE in preexisting guidelines seem applicable to patients with COVID-19.Show less >
Show more >Background:The association of pulmonary embolism (PE) with deep vein thrombosis (DVT) in patients with coronavirus disease 2019 (COVID-19) remains unclear, and the diagnostic accuracy of D-dimer tests for PE is unknown.Purpose:To conduct a meta-analysis of the study-level incidence of PE and DVT and to evaluate the diagnostic accuracy of D-dimer tests for PE from multicenter individual patient data.Materials and Methods:A systematic literature search identified studies evaluating the incidence of PE or DVT in patients with COVID-19 from January 1, 2020, to June 15, 2020. These outcomes were pooled using a random-effects model and were further evaluated using metaregression analysis. The diagnostic accuracy of D-dimer tests for PE was estimated based on individual patient data using the summary receiver operating characteristic curve.Results:Twenty-seven studies with 3342 patients with COVID-19 were included in the analysis. The pooled incidence rates of PE and DVT were 16.5% (95% CI: 11.6, 22.9; I2 = 0.93) and 14.8% (95% CI: 8.5, 24.5; I2 = 0.94), respectively. PE was more frequently found in patients who were admitted to the intensive care unit (ICU) (24.7% [95% CI: 18.6, 32.1] vs 10.5% [95% CI: 5.1, 20.2] in those not admitted to the ICU) and in studies with universal screening using CT pulmonary angiography. DVT was present in 42.4% of patients with PE. D-dimer tests had an area under the receiver operating characteristic curve of 0.737 for PE, and D-dimer levels of 500 and 1000 μg/L showed high sensitivity (96% and 91%, respectively) but low specificity (10% and 24%, respectively).Conclusion:Pulmonary embolism (PE) and deep vein thrombosis (DVT) occurred in 16.5% and 14.8% of patients with coronavirus disease 2019 (COVID-19), respectively, and more than half of patients with PE lacked DVT. The cutoffs of D-dimer levels used to exclude PE in preexisting guidelines seem applicable to patients with COVID-19.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Non spécifiée
Popular science :
Non
Source :
Files
- document
- Open access
- Access the document
- T202100409.pdf
- Open access
- Access the document
- document
- Open access
- Access the document
- T202100409.pdf
- Open access
- Access the document