Titre :

Viscoelastometric Testing to Assess Hemostasis of COVID-19: A Systematic Review

Auteur(s) :

Bareille, Marion [Auteur]
CHU UCL Namur
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Hardy, Michaël [Auteur]
CHU UCL Namur
Université Catholique de Louvain = Catholic University of Louvain [UCL]
Douxfils, Jonathan [Auteur]
Université de Namur [Namur] [UNamur]
Roullet, Stéphanie [Auteur]
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Lasne, Dominique [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Levy, Jerrold [Auteur]
Duke University [Durham]
Stépanian, Alain [Auteur]
Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) [IRSL]
Susen, Sophie [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Frère, Corinne [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Lecompte, Thomas [Auteur]
Université de Genève = University of Geneva [UNIGE]
Mullier, François [Auteur]
Université Catholique de Louvain = Catholic University of Louvain [UCL]
CHU UCL Namur

Titre de la revue :

Journal of clinical medicine

Pagination :

1740

Éditeur :

MDPI

Date de publication :

2021-04

ISSN :

2077-0383

Mot(s)-clé(s) en anglais :

COVID-19
ClotPro
Quantra
ROTEM
SARS-CoV-2
TEG
coronavirus disease 2019
severe acute respiratory syndrome coronavirus 2
sonorheometry
thromboelastography
thromboelastometry
viscoelastic test

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Infection by SARS-CoV-2 is associated with a high risk of thrombosis. The laboratory documentation of hypercoagulability and impaired fibrinolysis remains a challenge. Our aim was to assess the potential usefulness of ...
Lire la suite >Infection by SARS-CoV-2 is associated with a high risk of thrombosis. The laboratory documentation of hypercoagulability and impaired fibrinolysis remains a challenge. Our aim was to assess the potential usefulness of viscoelastometric testing (VET) to predict thrombotic events in COVID-19 patients according to the literature. We also (i) analyzed the impact of anticoagulation and the methods used to neutralize heparin, (ii) analyzed whether maximal clot mechanical strength brings more information than Clauss fibrinogen, and (iii) critically scrutinized the diagnosis of hypofibrinolysis. We performed a systematic search in PubMed and Scopus databases until 31st December 2020. VET methods and parameters, and patients' features and outcomes were extracted. VET was performed for 1063 patients (893 intensive care unit (ICU) and 170 non-ICU, 44 studies). There was extensive heterogeneity concerning study design, VET device used (ROTEM, TEG, Quantra and ClotPro) and reagents (with non-systematic use of heparin neutralization), timing of assay, and definition of hypercoagulable state. Notably, only 4 out of 25 studies using ROTEM reported data with heparinase (HEPTEM). The common findings were increased clot mechanical strength mainly due to excessive fibrinogen component and impaired to absent fibrinolysis, more conspicuous in the presence of an added plasminogen activator. Only 4 studies out of the 16 that addressed the point found an association of VETs with thrombotic events. So-called functional fibrinogen assessed by VETs showed a variable correlation with Clauss fibrinogen. Abnormal VET pattern, often evidenced despite standard prophylactic anticoagulation, tended to normalize after increased dosing. VET studies reported heterogeneity, and small sample sizes do not support an association between the poorly defined prothrombotic phenotype of COVID-19 and thrombotic events.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL