Title :

Derivation and Validation of a Predictive Score for Respiratory Failure Worsening Leading to Secondary Intubation in COVID-19: The CERES Score

Author(s) :

Gaudet, Alexandre [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Ghozlan, Benoit [Auteur]
Dupont, Annabelle [Auteur]
300166|||Institut Pasteur de Lille (VALID)
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Parmentier-Decrucq, Erika [Auteur]
Institut Pasteur de Lille
Rosa, Mickael [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Jeanpierre, Emmanuelle [Auteur]
Institut Pasteur de Lille
1059103|||Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD] (VALID)
Bayon, Constance [Auteur]
Tsicopoulos, Anne [Auteur]
Institut Pasteur de Lille
Duburcq, Thibault [Auteur]
Susen, Sophie [Auteur]
300166|||Institut Pasteur de Lille (VALID)
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Poissy, Julien [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Journal title :

Journal of clinical medicine

Volume number :

11

Pages :

2172

Publisher :

MDPI

Publication date :

2022-04-13

ISSN :

2077-0383

English keyword(s) :

COVID-19
late intubation
prediction
score
endothelial

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Chimie/Chimie théorique et/ou physique

English abstract : [en]

Predictive scores assessing the risk of respiratory failure in COVID-19 mostly focused on the prediction of early intubation. A combined assessment of clinical parameters and biomarkers of endotheliopathy could allow to ...
Show more >Predictive scores assessing the risk of respiratory failure in COVID-19 mostly focused on the prediction of early intubation. A combined assessment of clinical parameters and biomarkers of endotheliopathy could allow to predict late worsening of acute respiratory failure (ARF), subsequently warranting intubation in COVID-19. Retrospective single-center derivation (n = 92 subjects) and validation cohorts (n = 59 subjects), including severe COVID-19 patients with non-invasive respiratory support, were assessed for at least 48 h following intensive care unit (ICU) admission. We used stepwise regression to construct the COVID endothelial and respiratory failure (CERES) score in a derivation cohort, and secondly assessed its accuracy for the prediction of late ARF worsening, requiring intubation within 15 days following ICU admission in an independent validation cohort. Platelet count, fraction of inspired oxygen, and endocan measured on ICU admission were identified as the top three predictive variables for late ARF worsening and subsequently included in the CERES score. The area under the ROC curve of the CERES score to predict late ARF worsening was calculated in the derivation and validation cohorts at 0.834 and 0.780, respectively. The CERES score is a simple tool with good performances to predict respiratory failure worsening, leading to secondary intubation, in COVID-19 patients.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Glycobiology in fungal Pathogenesis and Clinical Applications

Submission date :

2024-02-27T16:05:26Z
2024-03-05T14:04:49Z
2024-03-05T14:07:08Z
2024-03-05T14:08:52Z