Title :

Examination of the endocrine-disrupting properties of "active chlorine generated from seawater by electrolysis" in response to the European Biocidal Products Regulation: current knowledge and methodological challenges

Author(s) :

Kinani, S. [Auteur]
Laboratoire National d’Hydraulique et Environnement [EDF R&D LNHE]
Achawi, S. [Auteur]
Ronga-Pezeret, S. [Auteur]
Piotrowski, A. [Auteur]
Gauthey-Lapize, C. [Auteur]
Tonk, I. [Auteur]
Wenker, M. [Auteur]
Nesslany, Fabrice [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]

Journal title :

Environmental Science Europe

Abbreviated title :

Environ. Sci Eur.

Volume number :

35

Pages :

86

Publication date :

2023-10-27

ISSN :

2190-4707

English keyword(s) :

Active chlorine
Biocidal products regulation
Endocrine disruptors
EFSA/ECHA TGD

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Currently, active chlorine is considered the most effective treatment for preventing biofouling of structures in contact with seawater. This compound falls under the scope of the EU Biocidal Products Regulation, which ...
Show more >Currently, active chlorine is considered the most effective treatment for preventing biofouling of structures in contact with seawater. This compound falls under the scope of the EU Biocidal Products Regulation, which includes since 2018 a requirement to assess all active ingredients for their potential endocrine-disrupting properties on humans and non-target organisms. Therefore, this study examines the endocrine-disrupting (ED) potential of active chlorine based on the European Chemicals Agency and European Food Safety Authority guidance (ED TGD). It includes two approaches: (i) a systematic literature review using appropriate search terms and (ii) an in silico assessment, both supported by expert judgement. Finally, the feasibility and relevance of in vitro tests were examined by considering the stability of chlorine and the applicability domain of the recommended in vitro assays.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2024-01-05T22:02:45Z
2024-02-23T10:05:49Z
2024-02-23T10:08:35Z