Title :

Diet-Induced Obesity Alters the Circadian Expression of Clock Genes in Mouse Gustatory Papillae

Author(s) :

Bernard, Arnaud [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer [LabEx LipSTIC]
Dastugue, Aurélie [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Maquart, Guillaume [Auteur]
Lipides - Nutrition - Cancer [Dijon - U1231] [LNC]
Delhaye, Stéphane [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Duez, Hélène [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Besnard, Philippe [Auteur]
Lipides - Nutrition - Cancer [Dijon - U1231] [LNC]

Journal title :

Frontiers in Physiology

Pages :

726

Publisher :

Frontiers

Publication date :

2020

ISSN :

1664-042X

English keyword(s) :

diet-induced obesity
circadian rhythm
gustatory papillae
orosensory sensitivity to lipids
taste sensitivity

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Physiologie [q-bio.TO]
Sciences du Vivant [q-bio]/Alimentation et Nutrition
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]

English abstract : [en]

Diet-induced obesity (DIO) is associated with a defect of the orosensory detection of dietary lipids in rodents. This dysfunction is not anecdotic since it might worsen the negative effects of obesity by promoting the ...
Show more >Diet-induced obesity (DIO) is associated with a defect of the orosensory detection of dietary lipids in rodents. This dysfunction is not anecdotic since it might worsen the negative effects of obesity by promoting the overconsumption of energy-dense foods. Previous studies have highlighted a progressive devaluation of reward value of lipid stimuli due to a desensitization of dopaminergic brain areas in DIO mice. Paradoxically, the putative deleterious impact of obesity on peripheral fat detection by the gustatory papillae remains poorly documented. Using a whole transcriptomic investigation of the circumvallate papillae (CVP), an analysis of CVP genes involved in fat taste transduction and signaling along the day, and two bottle choice tests, we have found that (i) CVP, known to house the most taste buds in the oral cavity, displays a genic circadian rhythm, (ii) DIO reduces the oscillation of key genes involved both in the circadian clock and lipid detection/signaling, and (iii) the gene invalidation of the clock gene Rev-Erbα does not significantly affect fat preference despite an oily solution intake slightly lower than littermate controls. Taken together these data bring the first demonstration that the gustatory function is under control of a peripheral clock in mammals, as already reported in fly and suggest that a disturbance of this rhythmicity might contribute to the lower fatty taste acuity found in obese miceShow less >

Language :

Anglais

Popular science :

Non

ANR Project :

Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du cancer

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL