Apolipoprotein F is reduced in humans with ...
Document type :
Compte-rendu et recension critique d'ouvrage
DOI :
Title :
Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism
Author(s) :
Deprince, Audrey [Auteur]
Hennuyer, Nathalie [Auteur]
Kooijman, Sander [Auteur]
Pronk, Amanda [Auteur]
Baugé, Eric [Auteur]
Lienard, Viktor [Auteur]
Verrijken, An [Auteur]
Dirinck, Eveline [Auteur]
Vonghia, Luisa [Auteur]
Woitrain, Eloïse [Auteur]
Kloosterhuis, Niels [Auteur]
Marez, Eléonore [Auteur]
Jacquemain, Pauline [Auteur]
Wolters, Justina [Auteur]
Lalloyer, Fanny [Auteur]
Eberlé, Delphine [Auteur]
Quemener, Sandrine [Auteur]
Vallez, Emmanuelle [Auteur]
Tailleux, Anne [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Kouach, Mostafa [Auteur]
Goossens, Jean‐francois [Auteur]
Raverdy, Violeta [Auteur]
Derudas, Bruno [Auteur]
Kuivenhoven, Jan Albert [Auteur]
Croyal, Mikaël [Auteur]
van de Sluis, Bart [Auteur]
Francque, Sven [Auteur]
Pattou, François [Auteur]
Rensen, Patrick [Auteur]
Staels, Bart [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Haas, Joel [Auteur]
Hennuyer, Nathalie [Auteur]
Kooijman, Sander [Auteur]
Pronk, Amanda [Auteur]
Baugé, Eric [Auteur]
Lienard, Viktor [Auteur]
Verrijken, An [Auteur]
Dirinck, Eveline [Auteur]
Vonghia, Luisa [Auteur]
Woitrain, Eloïse [Auteur]
Kloosterhuis, Niels [Auteur]
Marez, Eléonore [Auteur]
Jacquemain, Pauline [Auteur]
Wolters, Justina [Auteur]
Lalloyer, Fanny [Auteur]
Eberlé, Delphine [Auteur]
Quemener, Sandrine [Auteur]
Vallez, Emmanuelle [Auteur]
Tailleux, Anne [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Kouach, Mostafa [Auteur]
Goossens, Jean‐francois [Auteur]
Raverdy, Violeta [Auteur]
Derudas, Bruno [Auteur]
Kuivenhoven, Jan Albert [Auteur]
Croyal, Mikaël [Auteur]
van de Sluis, Bart [Auteur]
Francque, Sven [Auteur]
Pattou, François [Auteur]
Rensen, Patrick [Auteur]
Staels, Bart [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 [RNMCD]
Haas, Joel [Auteur]
Journal title :
Hepatology
Pages :
1287-1302
Publisher :
Wiley-Blackwell
Publication date :
2023-04-15
ISSN :
0270-9139
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background: NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD, in line with highly prevalent dyslipidemia in this population. Increased ...
Show more >Background: NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD, in line with highly prevalent dyslipidemia in this population. Increased plasma triglyceride (TG)‐rich lipoprotein (TRL) concentrations, an important risk factor for CVD, are closely linked with hepatic TG content. Therefore, it is of great interest to identify regulatory mechanisms of hepatic TRL production and remnant uptake in the setting of hepatic steatosis. Approach and Results: To identify liver‐regulated pathways linking intrahepatic and plasma TG metabolism, we performed transcriptomic analysis of liver biopsies from two independent cohorts of obese patients. Hepatic encoding apolipoprotein F ( APOF ) expression showed the fourth‐strongest negatively correlation with hepatic steatosis and the strongest negative correlation with plasma TG levels. The effects of adenoviral‐mediated human ApoF (hApoF) overexpression on plasma and hepatic TG were assessed in C57BL6/J mice. Surprisingly, hApoF overexpression increased both hepatic very low density lipoprotein (VLDL)‐TG secretion and hepatic lipoprotein remnant clearance, associated a ~25% reduction in plasma TG levels. Conversely, reducing endogenous ApoF expression reduced VLDL secretion in vivo , and reduced hepatocyte VLDL uptake by ~15% in vitro . Transcriptomic analysis of APOF ‐overexpressing mouse livers revealed a gene signature related to enhanced ApoB‐lipoprotein clearance, including increased expression of Ldlr and Lrp1 , among others. Conclusion: These data reveal a previously undescribed role for ApoF in the control of plasma and hepatic lipoprotein metabolism by favoring VLDL‐TG secretion and hepatic lipoprotein remnant particle clearance.Show less >
Show more >Background: NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD, in line with highly prevalent dyslipidemia in this population. Increased plasma triglyceride (TG)‐rich lipoprotein (TRL) concentrations, an important risk factor for CVD, are closely linked with hepatic TG content. Therefore, it is of great interest to identify regulatory mechanisms of hepatic TRL production and remnant uptake in the setting of hepatic steatosis. Approach and Results: To identify liver‐regulated pathways linking intrahepatic and plasma TG metabolism, we performed transcriptomic analysis of liver biopsies from two independent cohorts of obese patients. Hepatic encoding apolipoprotein F ( APOF ) expression showed the fourth‐strongest negatively correlation with hepatic steatosis and the strongest negative correlation with plasma TG levels. The effects of adenoviral‐mediated human ApoF (hApoF) overexpression on plasma and hepatic TG were assessed in C57BL6/J mice. Surprisingly, hApoF overexpression increased both hepatic very low density lipoprotein (VLDL)‐TG secretion and hepatic lipoprotein remnant clearance, associated a ~25% reduction in plasma TG levels. Conversely, reducing endogenous ApoF expression reduced VLDL secretion in vivo , and reduced hepatocyte VLDL uptake by ~15% in vitro . Transcriptomic analysis of APOF ‐overexpressing mouse livers revealed a gene signature related to enhanced ApoB‐lipoprotein clearance, including increased expression of Ldlr and Lrp1 , among others. Conclusion: These data reveal a previously undescribed role for ApoF in the control of plasma and hepatic lipoprotein metabolism by favoring VLDL‐TG secretion and hepatic lipoprotein remnant particle clearance.Show less >
Language :
Anglais
Popular science :
Non
Source :
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