Challenging Methicillin Resistance Detection ...
Document type :
Compte-rendu et recension critique d'ouvrage: Autre communication scientifique (congrès sans actes - poster - séminaire...)
DOI :
PMID :
Title :
Challenging Methicillin Resistance Detection in Bone and Joint Infections: Focus on the MRSA/SA SSTI (R) Strategy
Author(s) :
Titecat, Marie [Auteur]
Loiez, C. [Auteur]
Demaeght, F. [Auteur]
Leclerc, J. T. [Auteur]
Martinez, Théo [Auteur]
Dezeque, H. [Auteur]
Migaud, Henri [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab (ex-pmoi)]
Senneville, Eric [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Loiez, C. [Auteur]
Demaeght, F. [Auteur]
Leclerc, J. T. [Auteur]
Martinez, Théo [Auteur]
Dezeque, H. [Auteur]
Migaud, Henri [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab (ex-pmoi)]
Senneville, Eric [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Journal title :
Frontiers in Medicine
Pages :
553965
Publisher :
Frontiers media
Publication date :
2021-05-01
ISSN :
2296-858X
English keyword(s) :
bone and joint infections
methicillin resistance
PCR
conventionnal culture
Xpert MRSA/SA SSTI (R)
methicillin resistance
PCR
conventionnal culture
Xpert MRSA/SA SSTI (R)
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The genus Staphylococcus is the main causative agent of bone and joint infections (BJI) in which outcomes are impacted by both effective surgical and appropriate antimicrobial management. In this context, methicillin ...
Show more >The genus Staphylococcus is the main causative agent of bone and joint infections (BJI) in which outcomes are impacted by both effective surgical and appropriate antimicrobial management. In this context, methicillin resistance (MR) detection is a microbiological challenge to optimize the anti-staphylococcal drug coverage and to secure the surgical procedure. During the last decade, molecular tools have been developed to rapidly detect bacterial-resistant strains in clinical samples. The GeneXpert MRSA/SA SSTI® assay (Cepheid, Sunnyvale, CA, USA) is a real-time PCR method aimed at detecting methicillin-resistant Staphylococcus aureus (MRSA) in skin and soft tissues infections. In the literature, this test has been reported to be diverted from its original purpose to be evaluated in surgical samples. Within the current review, we update the GeneXpert MRSA/SA SSTI® assay performance in staphylococcal species determination (i.e., S. aureus vs. coagulase-negative species) together with MR genotype detection, when performed in osteoarticular infections.Show less >
Show more >The genus Staphylococcus is the main causative agent of bone and joint infections (BJI) in which outcomes are impacted by both effective surgical and appropriate antimicrobial management. In this context, methicillin resistance (MR) detection is a microbiological challenge to optimize the anti-staphylococcal drug coverage and to secure the surgical procedure. During the last decade, molecular tools have been developed to rapidly detect bacterial-resistant strains in clinical samples. The GeneXpert MRSA/SA SSTI® assay (Cepheid, Sunnyvale, CA, USA) is a real-time PCR method aimed at detecting methicillin-resistant Staphylococcus aureus (MRSA) in skin and soft tissues infections. In the literature, this test has been reported to be diverted from its original purpose to be evaluated in surgical samples. Within the current review, we update the GeneXpert MRSA/SA SSTI® assay performance in staphylococcal species determination (i.e., S. aureus vs. coagulase-negative species) together with MR genotype detection, when performed in osteoarticular infections.Show less >
Language :
Anglais
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