Enterocin DD14 can inhibit the infection ...
Document type :
Compte-rendu et recension critique d'ouvrage
Title :
Enterocin DD14 can inhibit the infection of eukaryotic cells with enveloped viruses
Author(s) :
Teiar, Radja [Auteur]
BioEcoAgro - UMR transfrontalière INRAE 1158
BioEcoAgro - Equipe 8 - Food and Digestive Microbial Ecosystems: Interactions - Dynamics - Application(s)
Sane, Famara [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Erol, Ismail [Auteur]
Bahcesehir University [Istanbul]
Nekoua, Magloire Pandoua [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lecouturier, Didier [Auteur]
BioEcoAgro - Equipe 4 - Secondary metabolites of microbial origin
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
NanoBioInterfaces - IEMN [NBI - IEMN]
Durdağı, Serdar [Auteur]
Bahcesehir University [Istanbul]
Hober, Didier [Auteur correspondant]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Université de Lille
Drider, Djamel [Auteur correspondant]
Université de Lille
BioEcoAgro - UMR transfrontalière INRAE 1158
BioEcoAgro - Equipe 8 - Food and Digestive Microbial Ecosystems: Interactions - Dynamics - Application(s)
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
BioEcoAgro - UMR transfrontalière INRAE 1158
BioEcoAgro - Equipe 8 - Food and Digestive Microbial Ecosystems: Interactions - Dynamics - Application(s)
Sane, Famara [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Erol, Ismail [Auteur]
Bahcesehir University [Istanbul]
Nekoua, Magloire Pandoua [Auteur]
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lecouturier, Didier [Auteur]
![refId](/themes/Mirage2//images/idref.png)
BioEcoAgro - Equipe 4 - Secondary metabolites of microbial origin
Boukherroub, Rabah [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
NanoBioInterfaces - IEMN [NBI - IEMN]
Durdağı, Serdar [Auteur]
Bahcesehir University [Istanbul]
Hober, Didier [Auteur correspondant]
![refId](/themes/Mirage2//images/idref.png)
Laboratoire de Virologie - ULR 3610 [Laboratoire de Virologie]
Université de Lille
Drider, Djamel [Auteur correspondant]
Université de Lille
BioEcoAgro - UMR transfrontalière INRAE 1158
BioEcoAgro - Equipe 8 - Food and Digestive Microbial Ecosystems: Interactions - Dynamics - Application(s)
Institut Charles Viollette (ICV) - ULR 7394 [ICV]
Journal title :
Archives of Microbiology
Pages :
269
Publisher :
Springer Verlag
Publication date :
2024-06-20
ISSN :
0302-8933
English keyword(s) :
Antiviral activity
Bacteriocins
Computational analysis
HCoV-229E
HSV-1
SARS-CoV-2.
Bacteriocins
Computational analysis
HCoV-229E
HSV-1
SARS-CoV-2.
HAL domain(s) :
Physique [physics]
Sciences de l'ingénieur [physics]
Sciences de l'ingénieur [physics]
English abstract : [en]
Bacteriocins are ribosomally synthesized bacterial peptides endowed with antibacterial, antiprotozoal, anticancer and antiviral activities. In the present study, we evaluated the antiviral activities of two bacteriocins, ...
Show more >Bacteriocins are ribosomally synthesized bacterial peptides endowed with antibacterial, antiprotozoal, anticancer and antiviral activities. In the present study, we evaluated the antiviral activities of two bacteriocins, enterocin DD14 (EntDD14) and lacticaseicin 30, against herpes simplex virus type 1 (HSV-1), human coronavirus 229E (HCoV-229E) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero, Huh7 and Vero E6 cells, respectively. In addition, the interactions of these bacteriocins with the envelope glycoprotein D of HSV-1 and the receptor binding domains of HCoV-229E and SARS-CoV-2 have been computationally evaluated using protein-protein docking and molecular dynamics simulations. HSV-1 replication in Vero cells was inhibited by EntDD14 and, to a lesser extent, by lacticaseicin 30 added to cells after virus inoculation. EntDD14 and lacticaseicin 30 had no apparent antiviral activity against HCoV-229E; however, EntDD14 was able to inhibit SARS-CoV-2 in Vero E6 cells. Further studies are needed to elucidate the antiviral mechanism of these bacteriocins.Show less >
Show more >Bacteriocins are ribosomally synthesized bacterial peptides endowed with antibacterial, antiprotozoal, anticancer and antiviral activities. In the present study, we evaluated the antiviral activities of two bacteriocins, enterocin DD14 (EntDD14) and lacticaseicin 30, against herpes simplex virus type 1 (HSV-1), human coronavirus 229E (HCoV-229E) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero, Huh7 and Vero E6 cells, respectively. In addition, the interactions of these bacteriocins with the envelope glycoprotein D of HSV-1 and the receptor binding domains of HCoV-229E and SARS-CoV-2 have been computationally evaluated using protein-protein docking and molecular dynamics simulations. HSV-1 replication in Vero cells was inhibited by EntDD14 and, to a lesser extent, by lacticaseicin 30 added to cells after virus inoculation. EntDD14 and lacticaseicin 30 had no apparent antiviral activity against HCoV-229E; however, EntDD14 was able to inhibit SARS-CoV-2 in Vero E6 cells. Further studies are needed to elucidate the antiviral mechanism of these bacteriocins.Show less >
Language :
Anglais
Popular science :
Non
Source :