Impact of age on tumor size in vulvar ...
Type de document :
Compte-rendu et recension critique d'ouvrage
URL permanente :
Titre :
Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group
Auteur(s) :
Raimond, E. [Auteur correspondant]
Risques cliniques et sécurité en santé des femmes et en santé périnatale [RISCQ]
Kerbage, Y. [Auteur]
Université de Lille
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Ouldamer, L. [Auteur]
CHU Trousseau [Tours]
Bendifallah, S. [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
CHU Tenon [AP-HP]
Carcopino, Xavier [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Institut méditerranéen de biodiversité et d'écologie marine et continentale [IMBE]
Koskas, M. [Auteur]
Bolze, P.A. [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Hospices Civils de Lyon [HCL]
Lavoué, V. [Auteur]
Institut de recherche en santé, environnement et travail [Irset]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Gauthier, T. [Auteur]
Service de Gynécologie-Obstétrique [CHU Limoges]
Graesslin, O. [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Fauconnier, A. [Auteur]
Risques cliniques et sécurité en santé des femmes et en santé périnatale [RISCQ]
Huchon, C. [Auteur]
Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables [ECEVE (U1123 / UMR_S_1123)]
Risques cliniques et sécurité en santé des femmes et en santé périnatale [RISCQ]
Kerbage, Y. [Auteur]
Université de Lille
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Ouldamer, L. [Auteur]
CHU Trousseau [Tours]
Bendifallah, S. [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
CHU Tenon [AP-HP]
Carcopino, Xavier [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Institut méditerranéen de biodiversité et d'écologie marine et continentale [IMBE]
Koskas, M. [Auteur]
Bolze, P.A. [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Hospices Civils de Lyon [HCL]
Lavoué, V. [Auteur]
Institut de recherche en santé, environnement et travail [Irset]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Gauthier, T. [Auteur]
Service de Gynécologie-Obstétrique [CHU Limoges]
Graesslin, O. [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Fauconnier, A. [Auteur]
Risques cliniques et sécurité en santé des femmes et en santé périnatale [RISCQ]
Huchon, C. [Auteur]
Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables [ECEVE (U1123 / UMR_S_1123)]
Titre de la revue :
EJSO - European Journal of Surgical Oncology
Pagination :
108482
Éditeur :
WB Saunders
Date de publication :
2024-09
ISSN :
0748-7983
Mot(s)-clé(s) en anglais :
Vulvar cancer
Tumor size
Age
Tumor size
Age
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Cancer
Résumé en anglais : [en]
Objective:Vulvar cancer is a rare pathology affecting mainly elderly women. This study aims to evaluate the impact of age on tumor size in vulvar cancer.Material and methods:This was a multicenter retrospective observational ...
Lire la suite >Objective:Vulvar cancer is a rare pathology affecting mainly elderly women. This study aims to evaluate the impact of age on tumor size in vulvar cancer.Material and methods:This was a multicenter retrospective observational study carried out between January 1, 1998, and December 31, 2020, in patients operated on for vulvar cancer. Univariate analysis was performed according to patients' age ≥ or <65 years. Factors associated with tumor size found to be significant according to age were then included in a multiple linear regression model.Results:Of the 382 patients included, there were 133 patients aged <65 years and 249 ≥ 65 years. Radical total vulvectomy surgeries were more frequently performed in women ≥65 years (n = 72 (28.9 %) versus n = 20 (15 %); p = 0.004). The median histological tumor size and interquartile range was 20 mm [13–29] in the <65 years and 30 mm [15–42] in patients ≥65 years (p = 0.001). Multiple linear regression showed that age ≥65 years had a regression coefficient of 7.15 95 % CI [2.32; 11.99] (p = 0.004), constituting a risk factor for larger histological tumour size. Patients aged ≥65 years old had a higher early complication rate (n = 150 (62 %) versus n = 56 (42.7 %), p = 0.001). They also had a greater risk of recurrence (HR = 1.89 (95%CI (1.24–2.89)), p = 0.003) with a worse overall survival (HR = 5.64 (95%CI (1.70–18.68)), p = 0.005).Conclusion:Age is a risk factor for larger tumor size, leading to more radical surgery and a greater risk of complications in already fragile patients, with a greater risk of recurrence and an impact on overall survival.Lire moins >
Lire la suite >Objective:Vulvar cancer is a rare pathology affecting mainly elderly women. This study aims to evaluate the impact of age on tumor size in vulvar cancer.Material and methods:This was a multicenter retrospective observational study carried out between January 1, 1998, and December 31, 2020, in patients operated on for vulvar cancer. Univariate analysis was performed according to patients' age ≥ or <65 years. Factors associated with tumor size found to be significant according to age were then included in a multiple linear regression model.Results:Of the 382 patients included, there were 133 patients aged <65 years and 249 ≥ 65 years. Radical total vulvectomy surgeries were more frequently performed in women ≥65 years (n = 72 (28.9 %) versus n = 20 (15 %); p = 0.004). The median histological tumor size and interquartile range was 20 mm [13–29] in the <65 years and 30 mm [15–42] in patients ≥65 years (p = 0.001). Multiple linear regression showed that age ≥65 years had a regression coefficient of 7.15 95 % CI [2.32; 11.99] (p = 0.004), constituting a risk factor for larger histological tumour size. Patients aged ≥65 years old had a higher early complication rate (n = 150 (62 %) versus n = 56 (42.7 %), p = 0.001). They also had a greater risk of recurrence (HR = 1.89 (95%CI (1.24–2.89)), p = 0.003) with a worse overall survival (HR = 5.64 (95%CI (1.70–18.68)), p = 0.005).Conclusion:Age is a risk factor for larger tumor size, leading to more radical surgery and a greater risk of complications in already fragile patients, with a greater risk of recurrence and an impact on overall survival.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
Date de dépôt :
2024-09-21T03:27:20Z