Late cortical disinhibition in relaxed ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Late cortical disinhibition in relaxed versus active hand muscles
Author(s) :
Caux-Dedeystère, Alexandre [Auteur]
Derambure, Philippe [Auteur]
Médicaments et Molécules pour agir sur les Systèmes Vivants (M2SV) - U1177
Médicaments et molécules pour les systèmes vivants - U 1177 [M2SV]
Médicaments et molécules pour les systèmes vivants - U 1177 [M2SV]
Devanne, Hervé [Auteur]
Derambure, Philippe [Auteur]

Médicaments et Molécules pour agir sur les Systèmes Vivants (M2SV) - U1177
Médicaments et molécules pour les systèmes vivants - U 1177 [M2SV]
Médicaments et molécules pour les systèmes vivants - U 1177 [M2SV]
Devanne, Hervé [Auteur]

Journal title :
Neuroscience
Abbreviated title :
Neuroscience
Volume number :
298
Pages :
52-62
Publication date :
2015-07-09
ISSN :
1873-7544
0306-4522
0306-4522
English keyword(s) :
late cortical disinhibition
long-interval intracortical facilitation
voluntary activity
motor cortex
long-interval intracortical facilitation
voluntary activity
motor cortex
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Recent research suggests that long-interval intracortical inhibition (LICI) is followed by a transitory period of late cortical disinhibition (LCD) that can even lead to a net increase in cortical excitability. The ...
Show more >Recent research suggests that long-interval intracortical inhibition (LICI) is followed by a transitory period of late cortical disinhibition (LCD) that can even lead to a net increase in cortical excitability. The relationship between LICI/LCD and voluntary drive remains poorly understood. Our study aims at investigating the influence of index abduction on LICI and LCD in an actively engaged muscle and a neighboring muscle, while varying the intensity of the conditioning stimulus (CS). Motor-evoked potentials (MEPs) were recorded from the first dorsal interosseus (FDI) and abductor digiti minimi (ADM) muscles in 13 subjects. Paired-pulses were delivered with 10 different interstimulus intervals (ranging from 60 to 290 ms). Whatever the condition (relaxed or active FDI), the test stimulus was set to evoke an MEP of 1mV. The time course of conditioned MEP amplitude was compared for relaxed and active conditions when the CS intensity was set to (i) 130% of the rest motor threshold (RMT) or (ii) to evoke the same size of MEP under both conditions. LICI lasted longer (i.e. disinhibition occurred later) at rest than during abduction when evoked either by similar or matched conditioning stimuli. No post-LICI facilitation was observed at rest - even when the CS intensity was set to 160% RMT. In contrast, long-interval intracortical facilitation (LICF) was observed in the quiescent ADM when FDI was active. LICF may then be associated with voluntary activity albeit with lack of topographic specificity.Show less >
Show more >Recent research suggests that long-interval intracortical inhibition (LICI) is followed by a transitory period of late cortical disinhibition (LCD) that can even lead to a net increase in cortical excitability. The relationship between LICI/LCD and voluntary drive remains poorly understood. Our study aims at investigating the influence of index abduction on LICI and LCD in an actively engaged muscle and a neighboring muscle, while varying the intensity of the conditioning stimulus (CS). Motor-evoked potentials (MEPs) were recorded from the first dorsal interosseus (FDI) and abductor digiti minimi (ADM) muscles in 13 subjects. Paired-pulses were delivered with 10 different interstimulus intervals (ranging from 60 to 290 ms). Whatever the condition (relaxed or active FDI), the test stimulus was set to evoke an MEP of 1mV. The time course of conditioned MEP amplitude was compared for relaxed and active conditions when the CS intensity was set to (i) 130% of the rest motor threshold (RMT) or (ii) to evoke the same size of MEP under both conditions. LICI lasted longer (i.e. disinhibition occurred later) at rest than during abduction when evoked either by similar or matched conditioning stimuli. No post-LICI facilitation was observed at rest - even when the CS intensity was set to 160% RMT. In contrast, long-interval intracortical facilitation (LICF) was observed in the quiescent ADM when FDI was active. LICF may then be associated with voluntary activity albeit with lack of topographic specificity.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Univ. Littoral Côte d’Opale
Univ. Artois
Université de Lille
Univ. Artois
Université de Lille
Collections :
Research team(s) :
Activité Physique, Muscle, Santé (APMS)
Submission date :
2019-09-24T07:26:50Z