Interactions between cyclodextrins and ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
Permalink :
Title :
Interactions between cyclodextrins and cellular components: Towards greener medical applications?
Author(s) :
Journal title :
Beilstein Journal of Organic Chemistry
Abbreviated title :
Beilstein J. Org. Chem.
Volume number :
12
Pages :
2644-2662
Publisher :
Beilstein-Institut
Publication date :
2016-12-07
ISSN :
1860-5397
English keyword(s) :
cellular interactions
cyclodextrins
endogenous substances
extraction
greener active ingredients
host–guest chemistry
lipids
cyclodextrins
endogenous substances
extraction
greener active ingredients
host–guest chemistry
lipids
HAL domain(s) :
Chimie/Chimie organique
English abstract : [en]
In the field of host–guest chemistry, some of the most widely used hosts are probably cyclodextrins (CDs). As CDs are able to increase the water solubility of numerous drugs by inclusion into their hydrophobic cavity, they ...
Show more >In the field of host–guest chemistry, some of the most widely used hosts are probably cyclodextrins (CDs). As CDs are able to increase the water solubility of numerous drugs by inclusion into their hydrophobic cavity, they have been widespread used to develop numerous pharmaceutical formulations. Nevertheless, CDs are also able to interact with endogenous substances that originate from an organism, tissue or cell. These interactions can be useful for a vast array of topics including cholesterol manipulation, treatment of Alzheimer’s disease, control of pathogens, etc. In addition, the use of natural CDs offers the great advantage of avoiding or reducing the use of common petroleum-sourced drugs. In this paper, the general features and applications of CDs have been reviewed as well as their interactions with isolated biomolecules leading to the formation of inclusion or exclusion complexes. Finally, some potential medical applications are highlighted throughout several examples.Show less >
Show more >In the field of host–guest chemistry, some of the most widely used hosts are probably cyclodextrins (CDs). As CDs are able to increase the water solubility of numerous drugs by inclusion into their hydrophobic cavity, they have been widespread used to develop numerous pharmaceutical formulations. Nevertheless, CDs are also able to interact with endogenous substances that originate from an organism, tissue or cell. These interactions can be useful for a vast array of topics including cholesterol manipulation, treatment of Alzheimer’s disease, control of pathogens, etc. In addition, the use of natural CDs offers the great advantage of avoiding or reducing the use of common petroleum-sourced drugs. In this paper, the general features and applications of CDs have been reviewed as well as their interactions with isolated biomolecules leading to the formation of inclusion or exclusion complexes. Finally, some potential medical applications are highlighted throughout several examples.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
ENSCL
CNRS
Centrale Lille
Univ. Artois
Université de Lille
CNRS
Centrale Lille
Univ. Artois
Université de Lille
Collections :
Research team(s) :
Colloïdes catalyse oxydation (CÏSCO)
Submission date :
2019-09-25T14:05:10Z
2023-12-15T09:47:32Z
2023-12-15T09:47:32Z
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