Title :

Using Milling to Explore Physical States: The Amorphous and Polymorphic Forms of Sulindac

Author(s) :

Latreche, Mansour [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
willart, Jean-François [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Guerain, Mathieu [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Hedoux, Alain [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Danede, Florence [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

Journal of Pharmaceutical Sciences

Volume number :

108

Pages :

2635-2642

Publisher :

Elsevier BV

Publication date :

2019-08-01

ISSN :

0022-3549

English keyword(s) :

milling
phase transformation(s)
phase transition(s)
polymorphism
glass
solid-state stability
Differential Scanning Calorimetry (DSC)
X-ray Powder Diffraction (XRD)
glass transition(s)
materials science

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]

English abstract : [en]

This article shows how milling can be used to explore the phase diagram of pharmaceuticals. This process has been applied to sulindac. A short milling has been found to trigger a polymorphic transformation between form II ...
Show more >This article shows how milling can be used to explore the phase diagram of pharmaceuticals. This process has been applied to sulindac. A short milling has been found to trigger a polymorphic transformation between form II and form I upon heating which is not seen in the nonmilled material. This possibility was clearly demonstrated to result from crystalline microstrains induced by the mechanical shocks. A long milling has been found to induce a total amorphization of the material. Moreover, the amorphous fraction produced during milling appears to have a complex recrystallization upon heating which depends on the milling time. The investigations have been mainly performed by differential scanning calorimetry and powder X-ray diffraction.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2019-11-21T12:52:35Z
2020-11-03T14:54:31Z