Title :

Evaluating the clinical relevance of a cognitive composite outcome measure: an analysis of 1414 participants from the 5-year guidage alzheimer's prevention trial

Author(s) :

Coley, Nicola [Auteur]
Gallini, Adeline [Auteur]
Ousset, Pierre-Jean [Auteur]
Vellas, Bruno [Auteur]
Andrieu, Sandrine [Auteur]

Journal title :

Alzheimer's & dementia . the journal of the Alzheimer's Association

Abbreviated title :

Alzheimers Dement

Volume number :

12

Pages :

1216-1225

Publication date :

2016-12-01

ISSN :

1552-5279

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Composite cognitive scores have been developed as primary outcome measures for preclinical/prevention trials for Alzheimer's disease (AD), mainly using observational data and with little consideration of clinical ...
Show more >Composite cognitive scores have been developed as primary outcome measures for preclinical/prevention trials for Alzheimer's disease (AD), mainly using observational data and with little consideration of clinical relevance. Secondary analysis of placebo group data from a 5-year AD prevention trial. The composite score was the average of the following z scores: MMSE orientation items, Free and Cued Selective Reminding Test, Category Fluency, Trail Making Test-part B. Composite score change from baseline differed significantly by age, APOE genotype, and CDR progression and AD dementia status. A 1 point decrease in baseline score was highly predictive of 5-year AD dementia risk (HR = 3.51, 95% CI, 2.62-4.71, P < .001). The 1 year minimum clinically important difference was estimated at -0.3 points and predicted AD dementia. We explored the clinical relevance of a composite score in a prevention trial setting. This type of analysis facilitates the interpretation of composite scores and informs power calculations.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:02:53Z