Title :

Transcranial magnetic stimulation and aging: effects on spatial learning and memory after sleep deprivation in octodon degus

Author(s) :

Estrada, C. [Auteur]
Fernandez-Gomez, Francisco-Jose [Auteur]
Lopez, D. [Auteur]
Gonzalez-Cuello, A. [Auteur]
Tunez, I. [Auteur]
Toledo, F. [Auteur]
Blin, Olivier [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Richardson, Jill C. [Auteur]
Fernandez-Villalba, E. [Auteur]
Herrero, Maria T. [Auteur]

Journal title :

Neurobiology of learning and memory

Abbreviated title :

Neurobiol. Learn. Mem.

Volume number :

125

Pages :

274-281

Publication date :

2015-11-01

ISSN :

1074-7427

English keyword(s) :

Transcranial magnetic stimulation (TMS)
Octodon degus
Sleep deprivation
Alzheimer disease
Aging

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The benefits of neuromodulatory procedures as a possible therapeutic application for cognitive rehabilitation have increased with the progress made in non-invasive modes of brain stimulation in aged-related disorders. ...
Show more >The benefits of neuromodulatory procedures as a possible therapeutic application for cognitive rehabilitation have increased with the progress made in non-invasive modes of brain stimulation in aged-related disorders. Transcranial magnetic stimulation (TMS) is a non-invasive method used to examine multiple facets of the human brain and to ameliorate the impairment in cognition caused by Alzheimer's disease (AD). The present study was designed to evaluate how a chronic TMS treatment could improve learning and memory functions after sleep deprivation (SD) in old Octodon degus. SD was executed by gently handling to keep the animals awake throughout the night. Thirty young and twenty-four old O. degus females were divided in six groups (control, acute and chronic TMS treatment). Behavioral tests included; Radial Arm Maze (RAM), Barnes Maze (BM) and Novel Object Recognition (NOR). Although learning and memory functions improved in young animals with only one session of TMS treatment, a significant improvement in cognitive performance was seen in old animals after 4 and 7days of TMS, depending on the task that was performed. No side effects were observed following, which showed therapeutic potential for improving age-related cognitive performance.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:36:30Z