Cognitive impairment after sleep deprivation ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Cognitive impairment after sleep deprivation rescued by transcranial magnetic stimulation application in octodon degus
Auteur(s) :
Estrada, C. [Auteur]
Lopez, D. [Auteur]
Conesa, A. [Auteur]
Fernandez-Gomez, Francisco-Jose [Auteur]
Gonzalez-Cuello, A. [Auteur]
Toledo, F. [Auteur]
Tunez, I. [Auteur]
Blin, Olivier [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Richardson, Jill C. [Auteur]
Fernandez-Villalba, E. [Auteur]
Herrero, Maria T. [Auteur]
Lopez, D. [Auteur]
Conesa, A. [Auteur]
Fernandez-Gomez, Francisco-Jose [Auteur]
Gonzalez-Cuello, A. [Auteur]
Toledo, F. [Auteur]
Tunez, I. [Auteur]
Blin, Olivier [Auteur]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Richardson, Jill C. [Auteur]
Fernandez-Villalba, E. [Auteur]
Herrero, Maria T. [Auteur]
Titre de la revue :
Neurotoxicity research
Nom court de la revue :
Neurotox. Res.
Numéro :
28
Pagination :
361-371
Date de publication :
2015-11-01
ISSN :
1029-8428
Mot(s)-clé(s) en anglais :
Learning
Memory
Octodon degus
Transcranial magnetic stimulation (TMS)
Sleep deprivation
Memory
Octodon degus
Transcranial magnetic stimulation (TMS)
Sleep deprivation
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Sleep is indispensable for maintaining regular daily life activities and is of fundamental physiological importance for cognitive performance. Sleep deprivation (SD) may affect learning capacity and the ability to form new ...
Lire la suite >Sleep is indispensable for maintaining regular daily life activities and is of fundamental physiological importance for cognitive performance. Sleep deprivation (SD) may affect learning capacity and the ability to form new memories, particularly with regard to hippocampus-dependent tasks. Transcranial magnetic stimulation (TMS) is a non-invasive procedure of electromagnetic induction that generates electric currents, activating nearby nerve cells in the stimulated cortical area. Several studies have looked into the potential therapeutic use of TMS. The present study was designed to evaluate how TMS could improve learning and memory functions following SD in Octodon degus. Thirty juvenile (18 months old) females were divided into three groups (control, acute, and chronic TMS treatment-with and without SD). TMS-treated groups were placed in plastic cylindrical cages designed to keep them immobile, while receiving head magnetic stimulation. SD was achieved by gently handling the animals to keep them awake during the night. Behavioral tests included radial arm maze (RAM), Barnes maze (BM), and novel object recognition. When TMS treatment was applied over several days, there was significant improvement of cognitive performance after SD, with no side effects. A single TMS session reduced the number of errors for the RAM test and improved latency and reduced errors for the BM test, which both evaluate spatial memory. Moreover, chronic TMS treatment brings about a significant improvement in both spatial and working memories.Lire moins >
Lire la suite >Sleep is indispensable for maintaining regular daily life activities and is of fundamental physiological importance for cognitive performance. Sleep deprivation (SD) may affect learning capacity and the ability to form new memories, particularly with regard to hippocampus-dependent tasks. Transcranial magnetic stimulation (TMS) is a non-invasive procedure of electromagnetic induction that generates electric currents, activating nearby nerve cells in the stimulated cortical area. Several studies have looked into the potential therapeutic use of TMS. The present study was designed to evaluate how TMS could improve learning and memory functions following SD in Octodon degus. Thirty juvenile (18 months old) females were divided into three groups (control, acute, and chronic TMS treatment-with and without SD). TMS-treated groups were placed in plastic cylindrical cages designed to keep them immobile, while receiving head magnetic stimulation. SD was achieved by gently handling the animals to keep them awake during the night. Behavioral tests included radial arm maze (RAM), Barnes maze (BM), and novel object recognition. When TMS treatment was applied over several days, there was significant improvement of cognitive performance after SD, with no side effects. A single TMS session reduced the number of errors for the RAM test and improved latency and reduced errors for the BM test, which both evaluate spatial memory. Moreover, chronic TMS treatment brings about a significant improvement in both spatial and working memories.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Équipe(s) de recherche :
Troubles cognitifs dégénératifs et vasculaires
Date de dépôt :
2019-11-27T13:37:20Z