Titre :

What is the clinical impact of cerebrospinal fluid biomarkers on final diagnosis and management in patients with mild cognitive impairment in clinical practice? results from a nation-wide prospective survey in france

Auteur(s) :

Cognat, Emmanuel [Auteur]
Mouton-Liger, François [Auteur]
Troussiere, Anne-Cecile [Auteur]
Wallon, David [Auteur]
Dumurgier, Julien [Auteur]
Magnin, Eloi [Auteur]
Duron, Emmanuelle [Auteur]
Gabelle, Audrey [Auteur]
Croisile, Bernard [Auteur]
De La Sayette, Vincent [Auteur]
Jager, Alain [Auteur]
Blanc, Frederic [Auteur]
Bouaziz-Amar, Elodie [Auteur]
Miguet-Alfonsi, Carole [Auteur]
Quillard-Muraine, Muriel [Auteur]
Schraen, Susanna [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Philippi, Nathalie [Auteur]
Beaufils, Emilie [Auteur]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Hannequin, Didier [Auteur]
Robert, Philippe-Henri [Auteur]
Hugon, Jacques [Auteur]
Paquet, Claire [Auteur]

Titre de la revue :

BMJ open

Nom court de la revue :

BMJ Open

Numéro :

9

Pagination :

e026380

Date de publication :

2019-05-30

ISSN :

2044-6055

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: New diagnostic criteria for Alzheimer's disease (AD) include cerebrospinal fluid (CSF) biomarkers that allow diagnosis at the stage of mild cognitive impairment (MCI). However, the impact of CSF biomarkers in ...
Lire la suite >OBJECTIVE: New diagnostic criteria for Alzheimer's disease (AD) include cerebrospinal fluid (CSF) biomarkers that allow diagnosis at the stage of mild cognitive impairment (MCI). However, the impact of CSF biomarkers in MCI populations in clinical practice has been poorly evaluated. The objective of this study is to assess the use and impact in clinical practice of AD CSF biomarkers in French memory clinics. METHODS: We performed a nation-wide, prospective survey between March 2012 and September 2014. Data over the same period was extracted from the French National Database (Banque Nationale Alzheimer, BNA) and compared with the results of the survey. METHODS: 29 secondary and tertiary memory clinics in France. METHODS: Clinicians prescribing lumbar puncture (LP) in order to measure AD CSF biomarkers. Clinicians completed a two-part questionnaire for each of their patients undergoing LP. Assessment of diagnosis, level of confidence before and after CSF biomarkers and impact on management in patients who underwent LP for CSF AD biomarkers in clinical routine. RESULTS: 977 questionnaires were completed, of which 61 were excluded because of unknown initial/final diagnosis or non-contributory CSF results. Of 916 patients reported, 153 (16.7%) had MCI as the initial diagnosis, of which 51 (33.3%) displayed an AD profile. CSF biomarkers resulted in a change in diagnosis in 44 patients (28.8%). Confidence level significantly increased after LP (8.3±1.4vs 6.73±1.18, p<0.0001), and CSF results modified management in 71/156 patients (46.4%), including 36 (23.5%) enrolled in clinical trials. Comparison of change in diagnosis with the BNA population revealed no difference (32.24%, p=0.4). CONCLUSIONS: This nation-wide survey, reflecting clinical practice in French memory clinics, describes the impact of CSF AD biomarkers in patients with MCI in clinical practice.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Alzheimer et Tauopathies
Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2019-11-27T14:30:26Z