Clinical characteristics and risk factors ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Clinical characteristics and risk factors of extensive macular atrophy with pseudodrusen the emap case-control national clinical trial
Auteur(s) :
Douillard, Aymeric [Auteur]
Picot, Marie-Christine [Auteur]
Delcourt, Cecile [Auteur]
Lacroux, Annie [Auteur]
Zanlonghi, Xavier [Auteur]
Puech, Bernard [Auteur]
Defoort-Dhellemmes, Sabine [Auteur]
Drumare, Isabelle [Auteur]
Jozefowicz, Elsa [Auteur]
Bocquet, Beatrice [Auteur]
Baudoin, Corinne [Auteur]
Al-Dain Marzouka, Nour [Auteur]
Perez-Roustit, Sarah [Auteur]
Arsene, Sophie [Auteur]
Gissot, Valerie [Auteur]
Devin, François [Auteur]
Arndt, Carl [Auteur]
Wolff, Benjamin [Auteur]
Mauget-Faysse, Martine [Auteur]
Quaranta, Maddalena [Auteur]
Mura, Thibault [Auteur]
Deplanque, Dominique [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Oubraham, Hassiba [Auteur]
Cohen, Salomon Yves [Auteur]
Gastaud, Pierre [Auteur]
Zambrowsky, Olivia [Auteur]
Creuzot-Garcher, Catherine [Auteur]
Mohand Said, Saddek [Auteur]
Blanco Garavito, Rocio [Auteur]
Souied, Eric [Auteur]
Sahel, Jose-Alain [Auteur]
Audo, Isabelle [Auteur]
Hamel, Christian [Auteur]
Meunier, Isabelle [Auteur]
Picot, Marie-Christine [Auteur]
Delcourt, Cecile [Auteur]
Lacroux, Annie [Auteur]
Zanlonghi, Xavier [Auteur]
Puech, Bernard [Auteur]
Defoort-Dhellemmes, Sabine [Auteur]
Drumare, Isabelle [Auteur]
Jozefowicz, Elsa [Auteur]
Bocquet, Beatrice [Auteur]
Baudoin, Corinne [Auteur]
Al-Dain Marzouka, Nour [Auteur]
Perez-Roustit, Sarah [Auteur]
Arsene, Sophie [Auteur]
Gissot, Valerie [Auteur]
Devin, François [Auteur]
Arndt, Carl [Auteur]
Wolff, Benjamin [Auteur]
Mauget-Faysse, Martine [Auteur]
Quaranta, Maddalena [Auteur]
Mura, Thibault [Auteur]
Deplanque, Dominique [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Oubraham, Hassiba [Auteur]
Cohen, Salomon Yves [Auteur]
Gastaud, Pierre [Auteur]
Zambrowsky, Olivia [Auteur]
Creuzot-Garcher, Catherine [Auteur]
Mohand Said, Saddek [Auteur]
Blanco Garavito, Rocio [Auteur]
Souied, Eric [Auteur]
Sahel, Jose-Alain [Auteur]
Audo, Isabelle [Auteur]
Hamel, Christian [Auteur]
Meunier, Isabelle [Auteur]
Titre de la revue :
Ophthalmology
Nom court de la revue :
Ophthalmology
Numéro :
123
Pagination :
1865-1873
Date de publication :
2016-09-01
ISSN :
0161-6420
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
To assess the association of clinical and biological factors with extensive macular atrophy with pseudodrusen (EMAP) characterized by bilateral macular atrophy occurring in patients aged 50 to 60 years and a rapid progression ...
Lire la suite >To assess the association of clinical and biological factors with extensive macular atrophy with pseudodrusen (EMAP) characterized by bilateral macular atrophy occurring in patients aged 50 to 60 years and a rapid progression to legal blindness within 5 to 10 years. A national matched case-control study. Participants were recruited in 10 French Departments of Ophthalmology and their associated clinical investigation centers. All 115 patients with EMAP had symptoms before the age of 55 years due to bilateral extensive macular atrophy with a larger vertical axis and diffuse pseudodrusen. Three controls without age-related macular degeneration (AMD) or retinal disease at fundus examination were matched for each patient with EMAP by gender, age, and geographic area (in total 415). Subjects and controls underwent an eye examination including color, red-free autofluorescent fundus photographs and spectral-domain optical coherence tomography with macular analysis. The interviews collected demographic, lifestyle, family and personal medical history, medications, and biological data. Associations of risk factors were estimated using conditional logistic regression. Extensive macular atrophy with pseudodrusen status (cases vs. controls). Extensive macular atrophy with pseudodrusen most frequently affected women (70 women, 45 men). After multivariate adjustment, family history of glaucoma or AMD was strongly associated with EMAP (odds ratio [OR], 2.3, P = 0.008 and OR, 1.5, P = 0.01, respectively). No association was found with cardiac diseases or their risk factors. Mild and moderate kidney disease and higher neutrophil rate were associated with a reduced risk of EMAP (OR, 0.58, P = 0.04; OR, 0.34, P = 0.01; and OR, 0.59, P = 0.003, respectively). On the contrary, eosinophilia (OR, 1.6; P = 0.0002), lymphocytosis (OR, 1.84; P = 0.0002), increased erythrocyte sedimentation rate (OR, 6.5; P = 0.0005), decreased CH50 (P = 0.001), and high plasma C3 level (P = 0.023) were significantly associated with a higher risk of EMAP. This study documents an association between EMAP and family history of AMD and glaucoma, a clear female predominance, and a systemic inflammatory profile. The reduced CH50 and increased C3 plasma values could reflect a more severe complement pathway dysfunction than in AMD, leading to early pseudodrusen and rapid development of geographic atrophy. There is no association of EMAP with AMD cardiac diseases or cardiac risks, including cigarette smoking.Lire moins >
Lire la suite >To assess the association of clinical and biological factors with extensive macular atrophy with pseudodrusen (EMAP) characterized by bilateral macular atrophy occurring in patients aged 50 to 60 years and a rapid progression to legal blindness within 5 to 10 years. A national matched case-control study. Participants were recruited in 10 French Departments of Ophthalmology and their associated clinical investigation centers. All 115 patients with EMAP had symptoms before the age of 55 years due to bilateral extensive macular atrophy with a larger vertical axis and diffuse pseudodrusen. Three controls without age-related macular degeneration (AMD) or retinal disease at fundus examination were matched for each patient with EMAP by gender, age, and geographic area (in total 415). Subjects and controls underwent an eye examination including color, red-free autofluorescent fundus photographs and spectral-domain optical coherence tomography with macular analysis. The interviews collected demographic, lifestyle, family and personal medical history, medications, and biological data. Associations of risk factors were estimated using conditional logistic regression. Extensive macular atrophy with pseudodrusen status (cases vs. controls). Extensive macular atrophy with pseudodrusen most frequently affected women (70 women, 45 men). After multivariate adjustment, family history of glaucoma or AMD was strongly associated with EMAP (odds ratio [OR], 2.3, P = 0.008 and OR, 1.5, P = 0.01, respectively). No association was found with cardiac diseases or their risk factors. Mild and moderate kidney disease and higher neutrophil rate were associated with a reduced risk of EMAP (OR, 0.58, P = 0.04; OR, 0.34, P = 0.01; and OR, 0.59, P = 0.003, respectively). On the contrary, eosinophilia (OR, 1.6; P = 0.0002), lymphocytosis (OR, 1.84; P = 0.0002), increased erythrocyte sedimentation rate (OR, 6.5; P = 0.0005), decreased CH50 (P = 0.001), and high plasma C3 level (P = 0.023) were significantly associated with a higher risk of EMAP. This study documents an association between EMAP and family history of AMD and glaucoma, a clear female predominance, and a systemic inflammatory profile. The reduced CH50 and increased C3 plasma values could reflect a more severe complement pathway dysfunction than in AMD, leading to early pseudodrusen and rapid development of geographic atrophy. There is no association of EMAP with AMD cardiac diseases or cardiac risks, including cigarette smoking.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Équipe(s) de recherche :
Troubles cognitifs dégénératifs et vasculaires
Date de dépôt :
2019-11-27T14:32:28Z