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Late outcomes of transcatheter aortic valve ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1016/j.jacc.2016.07.747
PMID :
27712776
Permalink :
http://hdl.handle.net/20.500.12210/16615
Title :
Late outcomes of transcatheter aortic valve replacement in high-risk patients the france-2 registry
Author(s) :
Gilard, Martine [Auteur]
Eltchaninoff, Helene [Auteur]
Donzeau-Gouge, Patrick [Auteur]
Chevreul, Karine [Auteur]
Fajadet, Jean [Auteur]
Leprince, Pascal [Auteur]
Leguerrier, Alain [Auteur]
Lievre, Michel [Auteur]
Prat, Alain [Auteur]
Teiger, Emmanuel [Auteur]
Lefevre, Thierry [Auteur]
Tchetche, Didier [Auteur]
Carrie, Didier [Auteur]
Himbert, Dominique [Auteur]
Albat, Bernard [Auteur]
Cribier, Alain [Auteur]
Sudre, Arnaud [Auteur]
Blanchard, Didier [Auteur]
Rioufol, Gilles [Auteur]
Collet, Frederic [Auteur]
Houel, Remi [Auteur]
Dos Santos, Pierre [Auteur]
Meneveau, Nicolas [Auteur]
Ghostine, Said [Auteur]
Manigold, Thibaut [Auteur]
Guyon, Philippe [Auteur]
Grisoli, Dominique [Auteur]
Le Breton, Herve [Auteur]
Delpine, Stéphane [Auteur]
Didier, Romain [Auteur]
Favereau, Xavier [Auteur]
Souteyrand, Geraud [Auteur]
Ohlmann, Patrick [Auteur]
Doisy, Vincent [Auteur]
Grollier, Gilles [Auteur]
Gommeaux, Antoine [Auteur]
Claudel, Jean-Philippe [Auteur]
Bourlon, François [Auteur]
Bertrand, Bernard [Auteur]
Laskar, Marc [Auteur]
Iung, Bernard [Auteur]
Journal title :
Journal of the American College of Cardiology
Abbreviated title :
J. Am. Coll. Cardiol.
Volume number :
68
Pages :
1637-1647
Publication date :
2016-10-11
ISSN :
0735-1097
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Transcatheter aortic valve replacement (TAVR) has revolutionized management of high-risk patients with severe aortic stenosis. However, survival and the incidence of severe complications have been assessed in relatively ...
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Transcatheter aortic valve replacement (TAVR) has revolutionized management of high-risk patients with severe aortic stenosis. However, survival and the incidence of severe complications have been assessed in relatively small populations and/or with limited follow-up. This report details late clinical outcome and its determinants in the FRANCE-2 (FRench Aortic National CoreValve and Edwards) registry. The FRANCE-2 registry prospectively included all TAVRs performed in France. Follow-up was scheduled at 30 days, at 6 months, and annually from 1 to 5 years. Standardized VARC (Valve Academic Research Consortium) outcome definitions were used. A total of 4,201 patients were enrolled between January 2010 and January 2012 in 34 centers. Approaches were transarterial (transfemoral 73%, transapical 18%, subclavian 6%, and transaortic or transcarotid 3%) or, in 18% of patients, transapical. Median follow-up was 3.8 years. Vital status was available for 97.2% of patients at 3 years. The 3-year all-cause mortality was 42.0% and cardiovascular mortality was 17.5%. In a multivariate model, predictors of 3-year all-cause mortality were male sex (p < 0.001), low body mass index, (p < 0.001), atrial fibrillation (p < 0.001), dialysis (p < 0.001), New York Heart Association functional class III or IV (p < 0.001), higher logistic EuroSCORE (p < 0.001), transapical or subclavian approach (p < 0.001 for both vs. transfemoral approach), need for permanent pacemaker implantation (p = 0.02), and post-implant periprosthetic aortic regurgitation grade ≥2 of 4 (p < 0.001). Severe events according to VARC criteria occurred mainly during the first month and subsequently in <2% of patients/year. Mean gradient, valve area, and residual aortic regurgitation were stable during follow-up. The FRANCE-2 registry represents the largest database available on late results of TAVR. Late mortality is largely related to noncardiac causes. Incidence rates of severe events are low after the first month. Valve performance remains stable over time.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
Collections :
  • Lille Neurosciences & Cognition (LilNCog) - U 1172
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T14:33:24Z
Université de Lille

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