Central venous-to-arterial pco2 difference, ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Central venous-to-arterial pco2 difference, arteriovenous oxygen content and outcome after adult cardiac surgery with cardiopulmonary bypass: a prospective observational study
Auteur(s) :
Moussa, Mouhamed D. [Auteur]
Durand, Arthur [Auteur]
Leroy, Guillaume [Auteur]
Vincent, Liu [Auteur]
Lamer, Antoine [Auteur]
Gantois, Guillaume [Auteur]
Joulin, Olivier [Auteur]
Ait-Ouarab, Slimane [Auteur]
Deblauwe, Delphine [Auteur]
Caroline, Brandt [Auteur]
Decoene, Christophe [Auteur]
Vincentelli, Andre [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011
VALLET, BENOIT [Auteur]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Kipnis, Eric [Auteur]
Recherche translationelle relations hôte-pathogènes
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Robin, Emmanuel [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011
Durand, Arthur [Auteur]
Leroy, Guillaume [Auteur]
Vincent, Liu [Auteur]
Lamer, Antoine [Auteur]
Gantois, Guillaume [Auteur]
Joulin, Olivier [Auteur]
Ait-Ouarab, Slimane [Auteur]
Deblauwe, Delphine [Auteur]
Caroline, Brandt [Auteur]
Decoene, Christophe [Auteur]
Vincentelli, Andre [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011
VALLET, BENOIT [Auteur]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Kipnis, Eric [Auteur]
Recherche translationelle relations hôte-pathogènes
Recherche translationnelle : relations hôte-pathogènes - EA 7366
Robin, Emmanuel [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011
Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011
Titre de la revue :
European journal of anaesthesiology
Nom court de la revue :
Eur J Anaesthesiol
Date de publication :
2019-01-16
ISSN :
1365-2346
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Rapid identification and treatment of tissue hypoxia reaching anaerobiosis (dysoxia) may reduce organ failure and the occurrence of major postoperative complications (MPC) after cardiac surgery. The predictive ability of ...
Lire la suite >Rapid identification and treatment of tissue hypoxia reaching anaerobiosis (dysoxia) may reduce organ failure and the occurrence of major postoperative complications (MPC) after cardiac surgery. The predictive ability of PCO2-based dysoxia biomarkers, central venous-to-arterial PCO2 difference (ΔPCO2) and ΔPCO2 to arteriovenous oxygen content difference ratio, is poorly studied in this setting. We evaluated the ability of PCO2-based tissue dysoxia biomarkers, blood lactate concentration and central venous oxygen saturation measured 2 h after admission to the ICU as predictors of MPC. A prospective, observational cohort study. Single-centre, academic hospital cardiovascular ICU. We included adult patients undergoing cardiac surgery with cardiopulmonary bypass and measured dysoxia biomarkers at ICU admission, and after 2, 6 and 24 h. The primary endpoint was MPC, a composite of cardiac and noncardiac MPC evaluated in the 48 h following surgery. After univariate analysis of MPC covariates including dysoxia biomarkers measured at 2 h, multivariate logistic regression analyses were performed to identify the association of these biomarkers with MPC for confounders. Areas under the receiver operating characteristic curves were determined for biomarkers which remained independently associated with MPC. MPC occurred in 56.5% of the 308 patients analysed. ΔPCO2, blood lactate concentration and central venous oxygen saturation measured at 2 h, but not ΔPCO2 to arteriovenous oxygen content difference ratio, were significantly associated with MPC. However, only ΔPCO2 was independently associated with MPC after multivariate analysis. The areas under the receiver operating characteristic curves of ΔPCO2 measured at 2 h for MPC prediction was 0.64 (95% CI 0.57 to 0.70, P < 0.001). After cardiac surgery with cardiopulmonary bypass, ΔPCO2 measured 2 h after ICU admission was the only dysoxia biomarker independently associated with MPC, but with limited performance. ClinicalTrials.gov, NCT03107572.Lire moins >
Lire la suite >Rapid identification and treatment of tissue hypoxia reaching anaerobiosis (dysoxia) may reduce organ failure and the occurrence of major postoperative complications (MPC) after cardiac surgery. The predictive ability of PCO2-based dysoxia biomarkers, central venous-to-arterial PCO2 difference (ΔPCO2) and ΔPCO2 to arteriovenous oxygen content difference ratio, is poorly studied in this setting. We evaluated the ability of PCO2-based tissue dysoxia biomarkers, blood lactate concentration and central venous oxygen saturation measured 2 h after admission to the ICU as predictors of MPC. A prospective, observational cohort study. Single-centre, academic hospital cardiovascular ICU. We included adult patients undergoing cardiac surgery with cardiopulmonary bypass and measured dysoxia biomarkers at ICU admission, and after 2, 6 and 24 h. The primary endpoint was MPC, a composite of cardiac and noncardiac MPC evaluated in the 48 h following surgery. After univariate analysis of MPC covariates including dysoxia biomarkers measured at 2 h, multivariate logistic regression analyses were performed to identify the association of these biomarkers with MPC for confounders. Areas under the receiver operating characteristic curves were determined for biomarkers which remained independently associated with MPC. MPC occurred in 56.5% of the 308 patients analysed. ΔPCO2, blood lactate concentration and central venous oxygen saturation measured at 2 h, but not ΔPCO2 to arteriovenous oxygen content difference ratio, were significantly associated with MPC. However, only ΔPCO2 was independently associated with MPC after multivariate analysis. The areas under the receiver operating characteristic curves of ΔPCO2 measured at 2 h for MPC prediction was 0.64 (95% CI 0.57 to 0.70, P < 0.001). After cardiac surgery with cardiopulmonary bypass, ΔPCO2 measured 2 h after ICU admission was the only dysoxia biomarker independently associated with MPC, but with limited performance. ClinicalTrials.gov, NCT03107572.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Institut Pasteur de Lille
Université de Lille
Inserm
Institut Pasteur de Lille
Université de Lille
Collections :
Date de dépôt :
2019-12-09T16:48:27Z