Hedonic sensitivity to natural rewards is ...
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Article dans une revue scientifique: Article original
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Title :
Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner
Author(s) :
Reynaert, Marie-Line [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Marrocco, Jordan [Auteur]
Centro Neurolesi Bonino Pulejo Messina [IRCCS Messina]
Mairesse, Jérôme [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Lionetto, Luana [Auteur]
Azienda Ospedaliera Sant'Andrea [Roma]
Simmaco, Maurizio [Auteur]
Azienda Ospedaliera Sant'Andrea [Roma]
Deruyter, Lucie [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Allorge, Delphine [Auteur]
171461|||Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Moles, Anna [Auteur]
Pittaluga, Anna [Auteur]
Maccari, Stefania [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
MORLEY-FLETCHER, Sara [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Van Camp, Gilles [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Nicoletti, Ferdinando [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Marrocco, Jordan [Auteur]
Centro Neurolesi Bonino Pulejo Messina [IRCCS Messina]
Mairesse, Jérôme [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Lionetto, Luana [Auteur]
Azienda Ospedaliera Sant'Andrea [Roma]
Simmaco, Maurizio [Auteur]
Azienda Ospedaliera Sant'Andrea [Roma]
Deruyter, Lucie [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Allorge, Delphine [Auteur]
![refId](/themes/Mirage2//images/idref.png)
171461|||Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Moles, Anna [Auteur]
Pittaluga, Anna [Auteur]
Maccari, Stefania [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
MORLEY-FLETCHER, Sara [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Van Camp, Gilles [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Nicoletti, Ferdinando [Auteur]
Istituto Neurologico Mediterraneo [NEUROMED I.R.C.C.S.]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Journal title :
Addiction Biology
Volume number :
21
Pages :
1072-1085
Publisher :
Wiley
Publication date :
2016-11
ISSN :
1355-6215
English keyword(s) :
Animal model
conditioned place preference
early life stress
palatable food
sex hormones
conditioned place preference
early life stress
palatable food
sex hormones
HAL domain(s) :
Chimie/Chimie théorique et/ou physique
English abstract : [en]
Palatable food is a strong activator of the reward circuitry and may cause addictive behavior leading to eating disorders. How early life events and sex interact in shaping hedonic sensitivity to palatable food is largely ...
Show more >Palatable food is a strong activator of the reward circuitry and may cause addictive behavior leading to eating disorders. How early life events and sex interact in shaping hedonic sensitivity to palatable food is largely unknown. We used prenatally restraint stressed (PRS) rats, which show abnormalities in the reward system and anxious/depressive-like behavior. Some of the hallmarks of PRS rats are known to be sex-dependent. We report that PRS enhanced and reduced milk chocolate-induced conditioned place preference in males and females, respectively. Male PRS rats also show increases in plasma dihydrotestosterone (DHT) levels and dopamine (DA) levels in the nucleus accumbens (NAc), and reductions in 5-hydroxytryptamine (5-HT) levels in the NAc and prefrontal cortex (PFC). In male rats, systemic treatment with the DHT-lowering drug finasteride reduced both milk chocolate preference and NAc DA levels. Female PRS rats showed lower plasma estradiol (E2) levels and lower DA levels in the NAc, and 5-HT levels in the NAc and PFC. E2 supplementation reversed the reduction in milk chocolate preference and PFC 5-HT levels. In the hypothalamus, PRS increased ERα and ERβ estrogen receptor and CARTP (cocaine-and-amphetamine receptor transcript peptide) mRNA levels in males, and 5-HT2C receptor mRNA levels in females. Changes were corrected by treatments with finasteride and E2, respectively. These new findings show that early life stress has a profound impact on hedonic sensitivity to high-palatable food via long-lasting changes in gonadal hormones. This paves the way to the development of hormonal strategies aimed at correcting abnormalities in the response to natural rewards.Show less >
Show more >Palatable food is a strong activator of the reward circuitry and may cause addictive behavior leading to eating disorders. How early life events and sex interact in shaping hedonic sensitivity to palatable food is largely unknown. We used prenatally restraint stressed (PRS) rats, which show abnormalities in the reward system and anxious/depressive-like behavior. Some of the hallmarks of PRS rats are known to be sex-dependent. We report that PRS enhanced and reduced milk chocolate-induced conditioned place preference in males and females, respectively. Male PRS rats also show increases in plasma dihydrotestosterone (DHT) levels and dopamine (DA) levels in the nucleus accumbens (NAc), and reductions in 5-hydroxytryptamine (5-HT) levels in the NAc and prefrontal cortex (PFC). In male rats, systemic treatment with the DHT-lowering drug finasteride reduced both milk chocolate preference and NAc DA levels. Female PRS rats showed lower plasma estradiol (E2) levels and lower DA levels in the NAc, and 5-HT levels in the NAc and PFC. E2 supplementation reversed the reduction in milk chocolate preference and PFC 5-HT levels. In the hypothalamus, PRS increased ERα and ERβ estrogen receptor and CARTP (cocaine-and-amphetamine receptor transcript peptide) mRNA levels in males, and 5-HT2C receptor mRNA levels in females. Changes were corrected by treatments with finasteride and E2, respectively. These new findings show that early life stress has a profound impact on hedonic sensitivity to high-palatable food via long-lasting changes in gonadal hormones. This paves the way to the development of hormonal strategies aimed at correcting abnormalities in the response to natural rewards.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Université de Lille
Institut Pasteur de Lille
CNRS
Université de Lille
Institut Pasteur de Lille
Collections :
Research team(s) :
Glycostress
Submission date :
2020-02-12T15:12:18Z
2021-06-03T15:46:57Z
2022-11-18T10:35:39Z
2022-11-18T11:36:34Z
2022-12-14T16:11:18Z
2022-12-14T16:12:04Z
2021-06-03T15:46:57Z
2022-11-18T10:35:39Z
2022-11-18T11:36:34Z
2022-12-14T16:11:18Z
2022-12-14T16:12:04Z
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