Insulin loaded iron magnetic nanoparticle–graphene ...
Type de document :
Article dans une revue scientifique
DOI :
URL permanente :
Titre :
Insulin loaded iron magnetic nanoparticle–graphene oxide composites: synthesis, characterization and application for in vivo delivery of insulin
Auteur(s) :
Turcheniuk, Kostiantyn [Auteur]
Université de Kiev
Khanal, Manakamana [Auteur]
Motorina, Anastasiia [Auteur]
Subramanian, Palaniappan [Auteur]
Barras, Alexandre [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Zaitsev, Vladimir [Auteur]
Taras Shevchenko National University of Kyiv
Kuncser, Victor [Auteur]
Leca, Aurel [Auteur]
Martoriati, Alain [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Bodart, Jean-Francois [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Université de Kiev
Khanal, Manakamana [Auteur]
Motorina, Anastasiia [Auteur]
Subramanian, Palaniappan [Auteur]
Barras, Alexandre [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Zaitsev, Vladimir [Auteur]
Taras Shevchenko National University of Kyiv
Kuncser, Victor [Auteur]
Leca, Aurel [Auteur]
Martoriati, Alain [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Bodart, Jean-Francois [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]
Boukherroub, Rabah [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Szunerits, Sabine [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Titre de la revue :
RSC Advances
Nom court de la revue :
RSC Adv.
Numéro :
4
Pagination :
865-875
Date de publication :
2014
ISSN :
2046-2069
Discipline(s) HAL :
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
One of the focal subjects in insulin delivery is the development of insulin formulations that protect the native insulin from degradation under acidic pH in the stomach. In this work we show, for the first time, that a ...
Lire la suite >One of the focal subjects in insulin delivery is the development of insulin formulations that protect the native insulin from degradation under acidic pH in the stomach. In this work we show, for the first time, that a graphene oxide (GO) based matrix can ensure the stability of insulin at low pH. GO and GO modified with 2-nitrodopamine coated magnetic particle (GO–MPdop) matrices loaded with insulin were prepared and the pH triggered release of the insulin was studied. The loading of insulin on the GO nanomaterials proved to be extremely high at pH < 5.4 with a loading capacity of 100 ± 3% on GO and 88 ± 3% on GO–MPdop. The insulin-containing GO matrices were stable at acidic pH, while insulin was released when exposed to basic solutions (pH = 9.2). Using Xenopus laevis oocytes as a model we showed that the meiotic resumption rate of GO and GO–MPdop remained unaltered when pre-treated in acidic conditions, while pre-incubated insulin (without GO nanomaterials) has lost almost entirely its maturation effect. These results suggest that GO based nanomatrices are promising systems for the protection of insulin.Lire moins >
Lire la suite >One of the focal subjects in insulin delivery is the development of insulin formulations that protect the native insulin from degradation under acidic pH in the stomach. In this work we show, for the first time, that a graphene oxide (GO) based matrix can ensure the stability of insulin at low pH. GO and GO modified with 2-nitrodopamine coated magnetic particle (GO–MPdop) matrices loaded with insulin were prepared and the pH triggered release of the insulin was studied. The loading of insulin on the GO nanomaterials proved to be extremely high at pH < 5.4 with a loading capacity of 100 ± 3% on GO and 88 ± 3% on GO–MPdop. The insulin-containing GO matrices were stable at acidic pH, while insulin was released when exposed to basic solutions (pH = 9.2). Using Xenopus laevis oocytes as a model we showed that the meiotic resumption rate of GO and GO–MPdop remained unaltered when pre-treated in acidic conditions, while pre-incubated insulin (without GO nanomaterials) has lost almost entirely its maturation effect. These results suggest that GO based nanomatrices are promising systems for the protection of insulin.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
Institut Catholique Lille
Université de Lille
ISEN
Univ. Valenciennes
CNRS
Centrale Lille
Université de Lille
ISEN
Univ. Valenciennes
CNRS
Centrale Lille
Collections :
Équipe(s) de recherche :
Régulation des signaux de division
Date de dépôt :
2020-02-12T15:44:31Z
2021-01-08T07:39:07Z
2021-01-08T07:39:07Z