Metastasis and the evolution of dispersal
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Titre :
Metastasis and the evolution of dispersal
Auteur(s) :
Tissot, Tazzio [Auteur]
Eco-Anthropologie et Ethnobiologie [EAE]
Institut d'écologie et des sciences de l'environnement de Paris [iEES Paris]
Massol, Francois [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Ujvari, Beata [Auteur]
Alix-Panabières, Catherine [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Loeuille, Nicolas [Auteur]
Institut d'écologie et des sciences de l'environnement de Paris [iEES Paris]
Thomas, Frédéric [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Eco-Anthropologie et Ethnobiologie [EAE]
Institut d'écologie et des sciences de l'environnement de Paris [iEES Paris]
Massol, Francois [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Ujvari, Beata [Auteur]
Alix-Panabières, Catherine [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Loeuille, Nicolas [Auteur]
Institut d'écologie et des sciences de l'environnement de Paris [iEES Paris]
Thomas, Frédéric [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Titre de la revue :
Proceedings of the Royal Society B: Biological Sciences
Pagination :
20192186
Éditeur :
Royal Society, The
Date de publication :
2019-11-27
ISSN :
0962-8452
Mot(s)-clé(s) en anglais :
cancer
metastasis
evolution
Subject Category: Evolution Subject Areas: ecology
cellular biology
evolution Keywords: dispersal
metastasis
evolution
Subject Category: Evolution Subject Areas: ecology
cellular biology
evolution Keywords: dispersal
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Génétique/Génétique des populations [q-bio.PE]
Résumé en anglais : [en]
Despite significant progress in oncology, metastasis remains the leading cause of mortality of cancer patients. Understanding the foundations of this phenomenon could help contain or even prevent it. As suggested by many ...
Lire la suite >Despite significant progress in oncology, metastasis remains the leading cause of mortality of cancer patients. Understanding the foundations of this phenomenon could help contain or even prevent it. As suggested by many ecologists and cancer biologists, metastasis could be considered through the lens of biological dispersal: the movement of cancer cells from their birth site (the primary tumour) to other habitats where they resume proliferation (metastatic sites). However, whether this model can consistently be applied to the emergence and dynamics of metastasis remains unclear. Here, we provide a broad review of various aspects of the evolution of dispersal in ecosystems. We investigate whether similar ecological and evolutionary principles can be applied to metastasis, and how these processes may shape the spatio-temporal dynamics of disseminating cancer cells. We further discuss complementary hypotheses and propose experimental approaches to test the relevance of the evolutionary ecology of dispersal in studying metastasis.Lire moins >
Lire la suite >Despite significant progress in oncology, metastasis remains the leading cause of mortality of cancer patients. Understanding the foundations of this phenomenon could help contain or even prevent it. As suggested by many ecologists and cancer biologists, metastasis could be considered through the lens of biological dispersal: the movement of cancer cells from their birth site (the primary tumour) to other habitats where they resume proliferation (metastatic sites). However, whether this model can consistently be applied to the emergence and dynamics of metastasis remains unclear. Here, we provide a broad review of various aspects of the evolution of dispersal in ecosystems. We investigate whether similar ecological and evolutionary principles can be applied to metastasis, and how these processes may shape the spatio-temporal dynamics of disseminating cancer cells. We further discuss complementary hypotheses and propose experimental approaches to test the relevance of the evolutionary ecology of dispersal in studying metastasis.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Projet ANR :
Source :
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