Emergence and dissemination of a ...
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Titre :
Emergence and dissemination of a linezolid-resistant Staphylococcus capitis clone in Europe
Auteur(s) :
Butin, Marine [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Martins-Simões, Patricia [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Pichon, B. [Auteur]
Public Health England [London]
Leyssene, D. [Auteur]
Centre Hospitalier de la Côte Basque [CHCB]
Bordes-Couecou, S. [Auteur]
Centre Hospitalier de la Côte Basque [CHCB]
Meugnier, Hélène [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Rouard, C. [Auteur]
Hôpital Antoine Béclère
Lemaitre, N. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Schramm, F. [Auteur]
Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë
Kearns, A. [Auteur]
Public Health England [London]
Spiliopoulou, I. [Auteur]
University of Patras
Hyyryläinen, H.-L. [Auteur]
National Institute for Health and Welfare [Helsinki]
Dumitrescu, Oana [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Vandenesch, François [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Dupieux, Céline [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Laurent, François [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Martins-Simões, Patricia [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Pichon, B. [Auteur]
Public Health England [London]
Leyssene, D. [Auteur]
Centre Hospitalier de la Côte Basque [CHCB]
Bordes-Couecou, S. [Auteur]
Centre Hospitalier de la Côte Basque [CHCB]
Meugnier, Hélène [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Rouard, C. [Auteur]
Hôpital Antoine Béclère
Lemaitre, N. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Schramm, F. [Auteur]
Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë
Kearns, A. [Auteur]
Public Health England [London]
Spiliopoulou, I. [Auteur]
University of Patras
Hyyryläinen, H.-L. [Auteur]
National Institute for Health and Welfare [Helsinki]
Dumitrescu, Oana [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Vandenesch, François [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Dupieux, Céline [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Laurent, François [Auteur]
Pathogénie des Staphylocoques – Staphylococcal Pathogenesis [StaPath]
Laboratoire de Bactériologie de l'Hôpital de la Croix-Rousse
Centre National de Reference des Staphylocoques
Titre de la revue :
Journal of Antimicrobial Chemotherapy
Pagination :
1014-1020
Éditeur :
Oxford University Press (OUP)
Date de publication :
2017
ISSN :
0305-7453
Mot(s)-clé(s) en anglais :
Adult
Aged
Anti-Bacterial Agents
Cluster Analysis
Drug Resistance
Bacterial
Electrophoresis
Gel
Pulsed-Field
Finland
France
Genes
Genome
Genotype
Greece
Humans
Linezolid
Male
Microbial Sensitivity Tests
Middle Aged
Molecular Epidemiology
Molecular Typing
Mutation
RNA
Ribosomal
23S
Sequence Analysis
DNA
Staphylococcal Infections
Staphylococcus
Young Adult
Aged
Anti-Bacterial Agents
Cluster Analysis
Drug Resistance
Bacterial
Electrophoresis
Gel
Pulsed-Field
Finland
France
Genes
Genome
Genotype
Greece
Humans
Linezolid
Male
Microbial Sensitivity Tests
Middle Aged
Molecular Epidemiology
Molecular Typing
Mutation
RNA
Ribosomal
23S
Sequence Analysis
DNA
Staphylococcal Infections
Staphylococcus
Young Adult
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Immunologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
Résumé en anglais : [en]
Objectives: We investigated the epidemiological, clinical, microbiological and genetic characteristics of linezolid-resistant (LZR) Staphylococcus capitis isolates from French ICUs, and compared them with LZR S. capitis ...
Lire la suite >Objectives: We investigated the epidemiological, clinical, microbiological and genetic characteristics of linezolid-resistant (LZR) Staphylococcus capitis isolates from French ICUs, and compared them with LZR S. capitis isolates from other European countries. Methods: All LZR isolates were subjected to antimicrobial susceptibility testing (AST) and the presence of cfr and optrA genes as well as mutations in the 23S rRNA and ribosomal proteins were investigated using specific PCR with sequencing. The genetic relationship between isolates was investigated using PFGE and WGS. Epidemiological data concerning LZR S. capitis were collected retrospectively in French microbiology laboratories. Results: Twenty-one LZR isolates were studied: 9 from France, 11 from Greece and 1 from Finland. All were resistant to methicillin and aminoglycosides. In addition, this unusual AST profile was identified in S. capitis isolates from seven French hospitals, and represented up to 12% of the S. capitis isolates in one centre. A G2576T mutation in 23S rRNA was identified in all isolates; cfr and optrA genes were absent. All isolates belonged to the same clone on the basis of their PFGE profiles, whatever their geographical origin. WGS found at most 212 SNPs between core genomes of the LZR isolates. Conclusions: We identified and characterized an LZR S. capitis clone disseminated in three European countries, harbouring the same multiple resistance and a G2576T mutation in the 23S rRNA. The possible unrecognized wider distribution of this clone, belonging to a species classically regarded as a low-virulence skin colonizer, is of major concern not least because of the increasing use of oxazolidinones.Lire moins >
Lire la suite >Objectives: We investigated the epidemiological, clinical, microbiological and genetic characteristics of linezolid-resistant (LZR) Staphylococcus capitis isolates from French ICUs, and compared them with LZR S. capitis isolates from other European countries. Methods: All LZR isolates were subjected to antimicrobial susceptibility testing (AST) and the presence of cfr and optrA genes as well as mutations in the 23S rRNA and ribosomal proteins were investigated using specific PCR with sequencing. The genetic relationship between isolates was investigated using PFGE and WGS. Epidemiological data concerning LZR S. capitis were collected retrospectively in French microbiology laboratories. Results: Twenty-one LZR isolates were studied: 9 from France, 11 from Greece and 1 from Finland. All were resistant to methicillin and aminoglycosides. In addition, this unusual AST profile was identified in S. capitis isolates from seven French hospitals, and represented up to 12% of the S. capitis isolates in one centre. A G2576T mutation in 23S rRNA was identified in all isolates; cfr and optrA genes were absent. All isolates belonged to the same clone on the basis of their PFGE profiles, whatever their geographical origin. WGS found at most 212 SNPs between core genomes of the LZR isolates. Conclusions: We identified and characterized an LZR S. capitis clone disseminated in three European countries, harbouring the same multiple resistance and a G2576T mutation in the 23S rRNA. The possible unrecognized wider distribution of this clone, belonging to a species classically regarded as a low-virulence skin colonizer, is of major concern not least because of the increasing use of oxazolidinones.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
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