SPECT imaging, clinical features, and ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
SPECT imaging, clinical features, and cognition before and after low doses of amisulpride in schizophrenic patients with the deficit syndrome.
Auteur(s) :
Vaiva, Guillaume [Auteur]
Thomas, Pierre [Auteur]
Llorca, Pierre-Michel [Auteur]
Dupont, Sylvie [Auteur]
Cottencin, Olivier [Auteur]
Devos, Patrick [Auteur]
Mazas, Olivier [Auteur]
Rascle, Claire [Auteur]
Steinling, Marc [Auteur]
Goudemand, Michel [Auteur]
Thomas, Pierre [Auteur]
Llorca, Pierre-Michel [Auteur]
Dupont, Sylvie [Auteur]
Cottencin, Olivier [Auteur]
Devos, Patrick [Auteur]
Mazas, Olivier [Auteur]
Rascle, Claire [Auteur]
Steinling, Marc [Auteur]
Goudemand, Michel [Auteur]
Titre de la revue :
Psychiatry Research
Nom court de la revue :
Psychiatry Res
Numéro :
115
Pagination :
37-48
Éditeur :
Elsevier
Date de publication :
2002-08-20
ISSN :
0165-1781
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
Résumé en anglais : [en]
The aim of the study was to examine the action of low-dose amisulpride (100 mg\/d), an atypical antipsychotic from the benzamide class with a high affinity for the D2 and D3 dopamine receptors, given for 4 weeks in 19 ...
Lire la suite >The aim of the study was to examine the action of low-dose amisulpride (100 mg\/d), an atypical antipsychotic from the benzamide class with a high affinity for the D2 and D3 dopamine receptors, given for 4 weeks in 19 schizophrenic patients with the deficit syndrome, in terms of clinical response, modifications in their cognitive performance and changes in brain perfusion values. A secondary objective was to distinguish between primary and secondary deficit, according to Carpenter's definition. Both efficacy and a relatively low rate of side effects of low-dose amisulpride in the deficit forms of schizophrenia were found as expected from earlier placebo-controlled studies. Our study found significant changes in the cerebral blood flow, before and after treatment, more marked in the frontal area and particularly in the dorso-lateral frontal area. A significant improvement of cognitive function was found after treatment, without a link to any particular changes in a loco-regional perfusion value. Finally, a distinction between primary and secondary deficit showed a higher percentage of clinical improvement in the patients with a secondary deficit. The psychometric and cerebral perfusion changes were no different in the two groups.Lire moins >
Lire la suite >The aim of the study was to examine the action of low-dose amisulpride (100 mg\/d), an atypical antipsychotic from the benzamide class with a high affinity for the D2 and D3 dopamine receptors, given for 4 weeks in 19 schizophrenic patients with the deficit syndrome, in terms of clinical response, modifications in their cognitive performance and changes in brain perfusion values. A secondary objective was to distinguish between primary and secondary deficit, according to Carpenter's definition. Both efficacy and a relatively low rate of side effects of low-dose amisulpride in the deficit forms of schizophrenia were found as expected from earlier placebo-controlled studies. Our study found significant changes in the cerebral blood flow, before and after treatment, more marked in the frontal area and particularly in the dorso-lateral frontal area. A significant improvement of cognitive function was found after treatment, without a link to any particular changes in a loco-regional perfusion value. Finally, a distinction between primary and secondary deficit showed a higher percentage of clinical improvement in the patients with a secondary deficit. The psychometric and cerebral perfusion changes were no different in the two groups.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Université de Lille
CNRS
Université de Lille
Date de dépôt :
2020-06-08T14:11:58Z