Title :

Differences in mutational processes and intra-tumour heterogeneity between organs: the local selective filter hypothesis

Author(s) :

Giraudeau, Mathieu [Auteur]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Sepp, Tuul [Auteur]
Institute of Ecology and Earth Sciences [Tartu]
Ujvari, Beata [Auteur]
Deakin University [Burwood]
Renaud, François [Auteur]
Génétique et évolution des maladies infectieuses [GEMI]
Tasiemski, Aurélie [Auteur]
Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 [Evo-Eco-Paléo (EEP)]
Roche, Benjamin [Auteur]
Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] [UMMISCO]
Centre de Recherches Ecologiques et Evolutives sur le Cancer [MIVEGEC-CREEC]
Capp, Jean-Pascal [Auteur]
Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés [LISBP]
Thomas, Frédéric [Auteur]
Génétique et évolution des maladies infectieuses [GEMI]

Journal title :

Evolution, Medicine, and Public Health

Pages :

139-146

Publisher :

Oxford : Oxford University Press

Publication date :

2019

ISSN :

2050-6201

English keyword(s) :

cancer
mutation
selection
intra-tumoural heterogeneity

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Extensive diversity (genetic, cytogenetic, epigenetic and phenotypic) exists within and between tumours, but reasons behind these variations, as well as their consistent hierarchical pattern between organs, are poorly ...
Show more >Extensive diversity (genetic, cytogenetic, epigenetic and phenotypic) exists within and between tumours, but reasons behind these variations, as well as their consistent hierarchical pattern between organs, are poorly understood at the moment. We argue that these phenomena are, at least partially, explainable by the evolutionary ecology of organs’ theory, in the same way that environmental adversity shapes mutation rates and level of polymorphism in organisms. Organs in organisms can be considered as specialized ecosystems that are, for ecological and evolutionary reasons, more or less efficient at suppressing tumours. When a malignancy does arise in an organ applying strong selection pressure on tumours, its constituent cells are expected to display a large range of possible surviving strategies, from hyper mutator phenotypes relying on bet-hedging to persist (high mutation rates and high diversity), to few poorly variable variants that become invisible to natural defences. In contrast, when tumour suppression is weaker, selective pressure favouring extreme surviving strategies is relaxed, and tumours are moderately variable as a result. We provide a comprehensive overview of this hypothesis.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Évolution, Écologie et Paléontologie (Evo Eco Paleo) - UMR 8198

Source :

Harvested from HAL