Plasma BCAA changes in Patients with NAFLD ...
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Titre :
Plasma BCAA changes in Patients with NAFLD are Sex Dependent 1
Auteur(s) :
Grzych, Guillaume [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
Vonghia, Luisa [Auteur]
Bout, Marie-Adélaïde [Auteur]
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
Weyler, Jonas [Auteur]
Verrijken, An [Auteur]
Dirinck, Eveline [Auteur]
Joncquel, Marie [Auteur]
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
van Gaal, Luc [Auteur]
Lestrelin, Réjane [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Francque, Sven [Auteur]
Tailleux, Anne [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Haas, Joël [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
Vonghia, Luisa [Auteur]
Bout, Marie-Adélaïde [Auteur]
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
Weyler, Jonas [Auteur]
Verrijken, An [Auteur]
Dirinck, Eveline [Auteur]
Joncquel, Marie [Auteur]
Institut de Biochimie et Biologie Moléculaire [CHRU Lille]
van Gaal, Luc [Auteur]
Lestrelin, Réjane [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Francque, Sven [Auteur]
Tailleux, Anne [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Haas, Joël [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Titre de la revue :
Journal of Clinical Endocrinology and Metabolism
Pagination :
dgaa175
Éditeur :
Endocrine Society
Date de publication :
2020-07-01
ISSN :
0021-972X
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Context: Plasma branched chain amino acid (BCAA) concentrations correlate positively with body mass index (BMI), measures of insulin resistance (IR), and severity of nonalcoholic fatty liver disease (NAFLD). Moreover, ...
Lire la suite >Context: Plasma branched chain amino acid (BCAA) concentrations correlate positively with body mass index (BMI), measures of insulin resistance (IR), and severity of nonalcoholic fatty liver disease (NAFLD). Moreover, plasma BCAA concentrations also differ between the sexes, which display different susceptibilities to cardio-metabolic diseases.Objective: Assess whether plasma BCAA concentrations associate with NAFLD severity independently of BMI, IR, and sex.Patients: Patients visiting the obesity clinic of the Antwerp University Hospital were consecutively recruited from 2006 to 2014.Design and setting: A cross-sectional study cohort of 112 obese patients (59 women and 53 men) was divided into 4 groups according to NAFLD severity. Groups were matched for sex, age, BMI, homeostatic model assessment of IR, and hemoglobin A1c.Main outcome measures: Fasting plasma BCAA concentrations were measured by tandem mass spectrometry using the aTRAQ™ method.Results: In the study cohort, a modest positive correlation was observed between plasma BCAA concentrations and NAFLD severity, as well as a strong effect of sex on plasma BCAA levels. Subgroup analysis by sex revealed that while plasma BCAA concentrations increased with severity of NAFLD in women, they tended to decrease in men. Additionally, only women displayed significantly increased plasma BCAAs with increasing fibrosis.Conclusion: Plasma BCAA concentrations display sex-dimorphic changes with increasing severity of NAFLD, independently of BMI, IR, and age. Additionally, plasma BCAA are associated with significant fibrosis in women, but not in men. These results highlight the importance of a careful consideration of sex as a major confounding factor in cross-sectional studies of NAFLD.Lire moins >
Lire la suite >Context: Plasma branched chain amino acid (BCAA) concentrations correlate positively with body mass index (BMI), measures of insulin resistance (IR), and severity of nonalcoholic fatty liver disease (NAFLD). Moreover, plasma BCAA concentrations also differ between the sexes, which display different susceptibilities to cardio-metabolic diseases.Objective: Assess whether plasma BCAA concentrations associate with NAFLD severity independently of BMI, IR, and sex.Patients: Patients visiting the obesity clinic of the Antwerp University Hospital were consecutively recruited from 2006 to 2014.Design and setting: A cross-sectional study cohort of 112 obese patients (59 women and 53 men) was divided into 4 groups according to NAFLD severity. Groups were matched for sex, age, BMI, homeostatic model assessment of IR, and hemoglobin A1c.Main outcome measures: Fasting plasma BCAA concentrations were measured by tandem mass spectrometry using the aTRAQ™ method.Results: In the study cohort, a modest positive correlation was observed between plasma BCAA concentrations and NAFLD severity, as well as a strong effect of sex on plasma BCAA levels. Subgroup analysis by sex revealed that while plasma BCAA concentrations increased with severity of NAFLD in women, they tended to decrease in men. Additionally, only women displayed significantly increased plasma BCAAs with increasing fibrosis.Conclusion: Plasma BCAA concentrations display sex-dimorphic changes with increasing severity of NAFLD, independently of BMI, IR, and age. Additionally, plasma BCAA are associated with significant fibrosis in women, but not in men. These results highlight the importance of a careful consideration of sex as a major confounding factor in cross-sectional studies of NAFLD.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Projet ANR :
Source :
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