Hepatic saturated fatty acid fraction is ...
Document type :
Compte-rendu et recension critique d'ouvrage
PMID :
Title :
Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
Author(s) :
Roumans, Kay [Auteur]
Maastricht University [Maastricht]
Lindeboom, Lucas [Auteur]
Maastricht University [Maastricht]
Maastricht University Medical Centre [MUMC]
Veeraiah, Pandichelvam [Auteur]
Maastricht University [Maastricht]
Maastricht University Medical Centre [MUMC]
Remie, Carlijn [Auteur]
Maastricht University [Maastricht]
Phielix, Esther [Auteur]
Maastricht University [Maastricht]
Havekes, Bas [Auteur]
Maastricht University Medical Centre [MUMC]
Bruls, Yvonne [Auteur]
Maastricht University [Maastricht]
Maastricht University Medical Centre [MUMC]
Brouwers, Martijn [Auteur]
Maastricht University Medical Centre [MUMC]
Ståhlman, Marcus [Auteur]
Göteborgs Universitet = University of Gothenburg [GU]
Sahlgrenska University Hospital [Gothenburg]
Alssema, Marjan [Auteur]
Peters, Harry [Auteur]
de Mutsert, Renée [Auteur]
Leiden University Medical Center [LUMC]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Taskinen, Marja-Riitta [Auteur]
Helsingin yliopisto = Helsingfors universitet = University of Helsinki
Borén, Jan [Auteur]
Göteborgs Universitet = University of Gothenburg [GU]
Sahlgrenska University Hospital [Gothenburg]
Schrauwen, Patrick [Auteur]
Maastricht University [Maastricht]
Schrauwen-Hinderling, Vera [Auteur correspondant]
Maastricht University [Maastricht]
Maastricht University Medical Centre [MUMC]
Maastricht University [Maastricht]
Lindeboom, Lucas [Auteur]
Maastricht University [Maastricht]
Maastricht University Medical Centre [MUMC]
Veeraiah, Pandichelvam [Auteur]
Maastricht University [Maastricht]
Maastricht University Medical Centre [MUMC]
Remie, Carlijn [Auteur]
Maastricht University [Maastricht]
Phielix, Esther [Auteur]
Maastricht University [Maastricht]
Havekes, Bas [Auteur]
Maastricht University Medical Centre [MUMC]
Bruls, Yvonne [Auteur]
Maastricht University [Maastricht]
Maastricht University Medical Centre [MUMC]
Brouwers, Martijn [Auteur]
Maastricht University Medical Centre [MUMC]
Ståhlman, Marcus [Auteur]
Göteborgs Universitet = University of Gothenburg [GU]
Sahlgrenska University Hospital [Gothenburg]
Alssema, Marjan [Auteur]
Peters, Harry [Auteur]
de Mutsert, Renée [Auteur]
Leiden University Medical Center [LUMC]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Taskinen, Marja-Riitta [Auteur]
Helsingin yliopisto = Helsingfors universitet = University of Helsinki
Borén, Jan [Auteur]
Göteborgs Universitet = University of Gothenburg [GU]
Sahlgrenska University Hospital [Gothenburg]
Schrauwen, Patrick [Auteur]
Maastricht University [Maastricht]
Schrauwen-Hinderling, Vera [Auteur correspondant]
Maastricht University [Maastricht]
Maastricht University Medical Centre [MUMC]
Journal title :
Nature Communications
Pages :
1891
Publisher :
Nature Publishing Group
Publication date :
2020-04-20
ISSN :
2041-1723
HAL domain(s) :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Hépatologie et Gastroentérologie
English abstract : [en]
Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of ...
Show more >Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.Show less >
Show more >Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.Show less >
Language :
Anglais
Popular science :
Non
European Project :
Source :
Files
- https://www.hal.inserm.fr/inserm-02649908/document
- Open access
- Access the document
- https://www.hal.inserm.fr/inserm-02649908/document
- Open access
- Access the document
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170906/pdf
- Open access
- Access the document
- https://www.hal.inserm.fr/inserm-02649908/document
- Open access
- Access the document
- document
- Open access
- Access the document
- s41467-020-15684-0.pdf
- Open access
- Access the document
- Open access
- Access the document
- document
- Open access
- Access the document
- s41467-020-15684-0.pdf
- Open access
- Access the document