PERSPECTIVES ON THE USE OF SUPER-ENHANCERS ...
Document type :
Compte-rendu et recension critique d'ouvrage
Title :
PERSPECTIVES ON THE USE OF SUPER-ENHANCERS AS A DEFINING FEATURE OF CELL/TISSUE- IDENTITY GENES
Author(s) :
Dubois-Chevalier, Julie [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Dubois, Vanessa [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Lefebvre, Philippe [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Eeckhoute, Jérôme [Auteur correspondant]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Dubois, Vanessa [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Lefebvre, Philippe [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Eeckhoute, Jérôme [Auteur correspondant]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Journal title :
Epigenomics
Pages :
715-723
Publisher :
Future Medicine
Publication date :
2020
ISSN :
1750-1911
English keyword(s) :
cell identity
transcriptome
epigenome
promoters
transcription factors
super enhancers
transcriptome
epigenome
promoters
transcription factors
super enhancers
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Super-enhancers (SE) have become a popular concept and are widely used as a feature defining key identity genes. Here, we provide perspectives on the use of SE to define and identify cell/tissue-identity genes. By mining ...
Show more >Super-enhancers (SE) have become a popular concept and are widely used as a feature defining key identity genes. Here, we provide perspectives on the use of SE to define and identify cell/tissue-identity genes. By mining SE and their associated genes using murine functional genomics data, we highlight and discuss current limitations and open questions regarding both the sensitivity and specificity of identity genes/TFs predicted by SE. In this context, we point to cell/tissue-specific promoters as an important additional level of information, which we propose to combine with SE when aiming to define potential identity genes.Show less >
Show more >Super-enhancers (SE) have become a popular concept and are widely used as a feature defining key identity genes. Here, we provide perspectives on the use of SE to define and identify cell/tissue-identity genes. By mining SE and their associated genes using murine functional genomics data, we highlight and discuss current limitations and open questions regarding both the sensitivity and specificity of identity genes/TFs predicted by SE. In this context, we point to cell/tissue-specific promoters as an important additional level of information, which we propose to combine with SE when aiming to define potential identity genes.Show less >
Language :
Anglais
Popular science :
Non
European Project :
Source :
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