Molecular Actions of PPARα in Lipid ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
Title :
Molecular Actions of PPARα in Lipid Metabolism and Inflammation
Author(s) :
Bougarne, Nadia [Auteur]
Weyers, Basiel [Auteur]
Desmet, Sofie [Auteur]
Deckers, Julie [Auteur]
Ray, David [Auteur]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
de Bosscher, Karolien [Auteur correspondant]
Weyers, Basiel [Auteur]
Desmet, Sofie [Auteur]
Deckers, Julie [Auteur]
Ray, David [Auteur]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
de Bosscher, Karolien [Auteur correspondant]
Journal title :
Endocrine reviews
Pages :
760-802
Publisher :
Endocrine Society
Publication date :
2018-10-01
ISSN :
0163-769X
English keyword(s) :
metabolism 5 6
inflammation
molecular mechanism
fibrates
PPAR alpha
inflammation
molecular mechanism
fibrates
PPAR alpha
HAL domain(s) :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
English abstract : [en]
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked anti-inflammatory capacities. The first-generation ...
Show more >Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked anti-inflammatory capacities. The first-generation PPARα agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPARα works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.Show less >
Show more >Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked anti-inflammatory capacities. The first-generation PPARα agonists, the fibrates, have however been hampered by drug-drug interaction issues, statin drop-in, and ill-designed cardiovascular intervention trials. Notwithstanding, understanding the molecular mechanisms by which PPARα works will enable control of its activities as a drug target for metabolic diseases with an underlying inflammatory component. Given its role in reshaping the immune system, the full potential of this nuclear receptor subtype as a versatile drug target with high plasticity becomes increasingly clear, and a novel generation of agonists may pave the way for novel fields of applications.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
ANR Project :
Source :
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