Coenzyme Q as an antiadipogenic factor.
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
PMID :
Titre :
Coenzyme Q as an antiadipogenic factor.
Auteur(s) :
Bour, Sandy [Auteur]
Institut des Maladies Métaboliques et Cardiovasculaires [I2MC]
Carmona, Maria-Carmen [Auteur]
Galinier, Anne [Auteur]
Neurobiologie, plasticité tissulaire et métabolisme énergétique [NPTME]
Caspar-Bauguil, Sylvie [Auteur]
van Gaal, Luc [Auteur]
Antwerp University Hospital [Edegem] [UZA]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Pénicaud, Luc [Auteur]
Centre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
Casteilla, Louis [Auteur correspondant]
Neurobiologie, plasticité tissulaire et métabolisme énergétique [NPTME]
Institut des Maladies Métaboliques et Cardiovasculaires [I2MC]
Carmona, Maria-Carmen [Auteur]
Galinier, Anne [Auteur]
Neurobiologie, plasticité tissulaire et métabolisme énergétique [NPTME]
Caspar-Bauguil, Sylvie [Auteur]
van Gaal, Luc [Auteur]
Antwerp University Hospital [Edegem] [UZA]
Staels, Bart [Auteur]
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Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Pénicaud, Luc [Auteur]
Centre des Sciences du Goût et de l'Alimentation [Dijon] [CSGA]
Casteilla, Louis [Auteur correspondant]
Neurobiologie, plasticité tissulaire et métabolisme énergétique [NPTME]
Titre de la revue :
Antioxidants and Redox Signaling
Pagination :
403-13
Éditeur :
Mary Ann Liebert
Date de publication :
2011-02-01
ISSN :
1523-0864
Mot(s)-clé(s) :
muscle
expression
expression
Mot(s)-clé(s) en anglais :
mitochondrial encephalomyopathy
uncoupling protein 2
coq(10) deficiency
oxidative stress
q(10) deficiency
adipose tissue
obesity
rosiglitazone
uncoupling protein 2
coq(10) deficiency
oxidative stress
q(10) deficiency
adipose tissue
obesity
rosiglitazone
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Coenzyme Q (CoQ) is not only the single antioxidant synthesized in humans but also an obligatory element of mitochondrial functions. We have previously reported CoQ deficiency in white adipose tissue of ob/ob mice. We ...
Lire la suite >Coenzyme Q (CoQ) is not only the single antioxidant synthesized in humans but also an obligatory element of mitochondrial functions. We have previously reported CoQ deficiency in white adipose tissue of ob/ob mice. We sought to determine (i) whether this deficit exists in all species and its relevance in human obesity and (ii) to what extent CoQ could be involved in adipocyte differentiation. Here we identified in rodents as well as in humans a specific very strong nonlinear negative correlation between CoQ content in subcutaneous adipose tissue and obesity indexes. This striking correlation reveals a threshold value similar in both species. This relative deficit in CoQ content in adipose tissue rapidly took place during the time course of high-fat-diet-induced obesity in mice. Adipocyte differentiation was assessed in vitro using the preadipocyte 3T3-F442A cell line. When CoQ synthesis was inhibited by a pharmacological approach using chlorobenzoic acid, this strongly triggered adipose differentiation. In contrast, adipogenesis was strongly inhibited when a long-term increase in CoQ content was obtained by overexpressing human 4-hydroxy benzoate acid polyprenyltransferase gene. Altogether, these data suggest that a strict level of CoQ remains essential for adipocyte differentiation, and its impairment is associated with obesity.Lire moins >
Lire la suite >Coenzyme Q (CoQ) is not only the single antioxidant synthesized in humans but also an obligatory element of mitochondrial functions. We have previously reported CoQ deficiency in white adipose tissue of ob/ob mice. We sought to determine (i) whether this deficit exists in all species and its relevance in human obesity and (ii) to what extent CoQ could be involved in adipocyte differentiation. Here we identified in rodents as well as in humans a specific very strong nonlinear negative correlation between CoQ content in subcutaneous adipose tissue and obesity indexes. This striking correlation reveals a threshold value similar in both species. This relative deficit in CoQ content in adipose tissue rapidly took place during the time course of high-fat-diet-induced obesity in mice. Adipocyte differentiation was assessed in vitro using the preadipocyte 3T3-F442A cell line. When CoQ synthesis was inhibited by a pharmacological approach using chlorobenzoic acid, this strongly triggered adipose differentiation. In contrast, adipogenesis was strongly inhibited when a long-term increase in CoQ content was obtained by overexpressing human 4-hydroxy benzoate acid polyprenyltransferase gene. Altogether, these data suggest that a strict level of CoQ remains essential for adipocyte differentiation, and its impairment is associated with obesity.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Commentaire :
WOS: 000285876900007
Source :